| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_029597m |
| Family | AA3 |
| Protein Properties | Length: 582 Molecular Weight: 63772.2 Isoelectric Point: 9.3088 |
| Chromosome | Chromosome/Scaffold: 00341 Start: 974422 End: 976580 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 49 | 574 | 0 |
| YYDYIIVGGGTSGCPLAATLSENATVLVLERGGSPYGNTNITNIGNFVASISDTSPNSPSQSFISEDGVYNTRARVLGGGSSLNAGFYTHASADFVKESG WSEKLANASYEWIEKKVVFEPTMLQWQSAVRNGLIEAGVSPYNGFTYDHVSGTKIGGSIFDADGHRHTAADLLEYAKPRNILVYLHATVLKILFTGKGRP WARPRAYGVTFEDDSGTRHTAFLNRNLWSEIILSAGAIGSPQLLMLSGIGPAYHLRAHGIPVVLDHPMVGQGMADNPMNLLFVPSPVPVEVSLIQVVGIT QFGSFIETASGLTFAYSWAQGFVRDYELSLNKTGQQSILTPEAMARAVETVNSLVNATLKGGIILEKVTGPRSTGDLKLRTTNPNDNPSVKFNYFKDPED LKKCVQGMKTIINIINTKAFSKFRYKHVPVQALISLMANLPVNLRPRHSTTTISLEQFCIDTVMTIWHYHGGCQVGKVIDRKYRVRGVDGLRVIDSSTFL GSPGTNPQATVMMLGRYMGRMMMRER | |||
| Full Sequence |
|---|
| Protein Sequence Length: 582 Download |
| MGLLSWKFIR ILLSGIFLFH GFCHPLPQIA SELHYTFVHE ATSAPAVLYY DYIIVGGGTS 60 GCPLAATLSE NATVLVLERG GSPYGNTNIT NIGNFVASIS DTSPNSPSQS FISEDGVYNT 120 RARVLGGGSS LNAGFYTHAS ADFVKESGWS EKLANASYEW IEKKVVFEPT MLQWQSAVRN 180 GLIEAGVSPY NGFTYDHVSG TKIGGSIFDA DGHRHTAADL LEYAKPRNIL VYLHATVLKI 240 LFTGKGRPWA RPRAYGVTFE DDSGTRHTAF LNRNLWSEII LSAGAIGSPQ LLMLSGIGPA 300 YHLRAHGIPV VLDHPMVGQG MADNPMNLLF VPSPVPVEVS LIQVVGITQF GSFIETASGL 360 TFAYSWAQGF VRDYELSLNK TGQQSILTPE AMARAVETVN SLVNATLKGG IILEKVTGPR 420 STGDLKLRTT NPNDNPSVKF NYFKDPEDLK KCVQGMKTII NIINTKAFSK FRYKHVPVQA 480 LISLMANLPV NLRPRHSTTT ISLEQFCIDT VMTIWHYHGG CQVGKVIDRK YRVRGVDGLR 540 VIDSSTFLGS PGTNPQATVM MLGRYMGRMM MRERITKWKA Y* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK02106 | PRK02106 | 2.0e-12 | 419 | 547 | 133 | + choline dehydrogenase; Validated | ||
| PRK02106 | PRK02106 | 1.0e-37 | 50 | 323 | 326 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 7.0e-40 | 51 | 547 | 557 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 5.0e-44 | 50 | 559 | 562 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 31 | 559 | 545 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI31862.1 | 0 | 1 | 574 | 1 | 537 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002267807.1 | 0 | 1 | 574 | 1 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002267848.1 | 0 | 1 | 574 | 1 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002298074.1 | 0 | 4 | 577 | 3 | 572 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002510860.1 | 0 | 1 | 580 | 1 | 576 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1ju2_B | 0 | 34 | 574 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 1ju2_A | 0 | 34 | 574 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_B | 0 | 34 | 574 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_A | 0 | 34 | 574 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdn_B | 0 | 34 | 574 | 11 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cutin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
| cutin biosynthesis | RXN-9802 | EC-1.1.1 | 16-hydroxypalmitate dehydrogenase |
| suberin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
