Basic Information | |
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Species | Manihot esculenta |
Cazyme ID | cassava4.1_030005m |
Family | CBM57 |
Protein Properties | Length: 845 Molecular Weight: 93595.5 Isoelectric Point: 5.4634 |
Chromosome | Chromosome/Scaffold: 07478 Start: 908929 End: 911463 |
Description | hercules receptor kinase 2 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 228 | 382 | 1.1e-21 |
YRLNVGGPDIKPNQDSDFWRIWELDSSYMITENAGDEITSNSNITYASINGSSVAPLLVYKTARTMSKTEVLEKRFNMSWKFEVHPDFDYLVRLHFCELE YDKANQRIFRIYVNNRTAADNFDIYVRAGGKNKAYHQDYFDAVSSNINTLWIQLG |
Full Sequence |
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Protein Sequence Length: 845 Download |
MENIQKGELL GLLYLVIMFI STSSGEAESK SFFINCGTNA SVTVDDRRWV GDMVPNNNVT 60 LVSDPESTTA TSNASAAAPL GPLYETARIF TGALNFTFEG IQGNYFVRLH FCPFPSDNFN 120 VNESSFSVMA NGLKLVSEFN VPGEISHKNL YLQRSNSNSS SFSLVREYIL FSLDFLVLEF 180 VPSKGSFGFI NAIEIVSVAD NLFEDPVSKV GGNVANLNLG GRGIETMYRL NVGGPDIKPN 240 QDSDFWRIWE LDSSYMITEN AGDEITSNSN ITYASINGSS VAPLLVYKTA RTMSKTEVLE 300 KRFNMSWKFE VHPDFDYLVR LHFCELEYDK ANQRIFRIYV NNRTAADNFD IYVRAGGKNK 360 AYHQDYFDAV SSNINTLWIQ LGPDTTAGGS GTDALLNGLE IFKLSRNGNL AYVDKFDSTG 420 NSTKNSNSWI LWLVIGAGGV CILILAIACI LIFFFCRTRK KELSDTKDNA PGWRPLFLHG 480 SIASSIGHAK GGLQNPNGST ASTRLGKRFT FAEIRAATNN FDESLVIGVG GFGKVYKGEI 540 ECGSLAAIKR ANPQSEQGLA EFETEIEMLS KLRHRHLVSM IGFCEEQNEM ILVYEYMANG 600 TLRSHLFGSN LPPLTWKQRL EACIGAARGL HYLHTGADRG IIHRDVKTTN ILLDENFVAK 660 MADFGLSKTG PAWDHTHVST AVKGSFGYLD PEYFRRQQLT EKSDVYSFGV VLFEAVCARA 720 VINPTLPKDQ INLAEWAMRW QRQRSLETII DPNLSGTYCP ESLKKYGEIA EKCLADDGKN 780 RPTMGEVLWH LEYVLQLHEA WMRAGVTESS ISSSNQALED PEEGVQGKEQ QTSNEGTSKA 840 QSDG* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam07714 | Pkinase_Tyr | 3.0e-49 | 526 | 791 | 272 | + Protein tyrosine kinase. | ||
smart00221 | STYKc | 2.0e-52 | 526 | 791 | 275 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
smart00219 | TyrKc | 1.0e-52 | 526 | 791 | 275 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
cd00192 | PTKc | 6.0e-53 | 526 | 792 | 282 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
pfam12819 | Malectin_like | 3.0e-57 | 34 | 404 | 395 | + Carbohydrate-binding protein of the ER. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases. |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI31024.1 | 0 | 8 | 841 | 2 | 832 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002264211.1 | 0 | 1 | 841 | 40 | 877 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002299052.1 | 0 | 1 | 844 | 1 | 840 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002330599.1 | 0 | 1 | 822 | 1 | 821 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002523186.1 | 0 | 1 | 844 | 1 | 842 | kinase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2qkw_B | 0 | 508 | 800 | 28 | 319 | A Chain A, Structural Basis For Activation Of Plant Immunity By Bacterial Effector Protein Avrpto |
PDB | 3hgk_D | 0 | 508 | 800 | 28 | 319 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_C | 0 | 508 | 800 | 28 | 319 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_B | 0 | 508 | 800 | 28 | 319 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_A | 0 | 508 | 800 | 28 | 319 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
Transmembrane Domains | ||||
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Start | End | |||
433 | 455 |
Signal Peptide | ||||
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Cleavage Site | ||||
27 |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
ES805185 | 337 | 457 | 787 | 0 |
EX357602 | 257 | 531 | 787 | 0 |
DN217707 | 258 | 531 | 788 | 0 |
ES795034 | 259 | 467 | 723 | 0 |
DY971329 | 298 | 500 | 797 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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