| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_031502m |
| Family | GH79 |
| Protein Properties | Length: 520 Molecular Weight: 56923.1 Isoelectric Point: 6.6426 |
| Chromosome | Chromosome/Scaffold: 03049 Start: 99685 End: 102613 |
| Description | glucuronidase 3 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 27 | 512 | 0 |
| DHDFICATLDWWPPDKCDYGTCSWGRASFLNLDLTNPILLNAIKAFSPLKIRMGGTLQDKVIYERQGEPCTTFVKNSSEIFSFSQGCLSMSRWDELNNFF RQAVATVIFGLNALKGRTIAPDGSAVGAWDTSDAESLIRYTVNRGYRIHGWELGNELSGNGVGARVSADQYASDVNILQNLVDNIHTGFKDKPLVLAPGG FFDANWFKEFIDKTPKSLQVVTQHIYNLGPGVDDHLMDKILDPAYLDHVSQTFSSLREILKSSGTQAVAWVGEAGGAYNSGHNQVTNAFVSSFWYLDQLG LSSSYDTKTHCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNALSTSFSGTKKLRAYAHCSKATQGITLLLINLDGNTTVQVSISTENVARNGTW TLQEYQNQRENFARITRGSKVDENIREEYHLTAKDGDLHSQIVLLNGKILAVNSSGAIPPLDPIRVGLSNPITIAPFSIVFAQISN | |||
| Full Sequence |
|---|
| Protein Sequence Length: 520 Download |
| KSSVFVASQS TEGTVFINGT ASIGSTDHDF ICATLDWWPP DKCDYGTCSW GRASFLNLDL 60 TNPILLNAIK AFSPLKIRMG GTLQDKVIYE RQGEPCTTFV KNSSEIFSFS QGCLSMSRWD 120 ELNNFFRQAV ATVIFGLNAL KGRTIAPDGS AVGAWDTSDA ESLIRYTVNR GYRIHGWELG 180 NELSGNGVGA RVSADQYASD VNILQNLVDN IHTGFKDKPL VLAPGGFFDA NWFKEFIDKT 240 PKSLQVVTQH IYNLGPGVDD HLMDKILDPA YLDHVSQTFS SLREILKSSG TQAVAWVGEA 300 GGAYNSGHNQ VTNAFVSSFW YLDQLGLSSS YDTKTHCRQT LIGGNYGLLN TTTFVPNPDY 360 YSALLWHRLM GRNALSTSFS GTKKLRAYAH CSKATQGITL LLINLDGNTT VQVSISTENV 420 ARNGTWTLQE YQNQRENFAR ITRGSKVDEN IREEYHLTAK DGDLHSQIVL LNGKILAVNS 480 SGAIPPLDPI RVGLSNPITI APFSIVFAQI SNITVPACI* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 12 | 326 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI25561.1 | 0 | 12 | 518 | 29 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002283254.1 | 0 | 1 | 518 | 19 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283260.1 | 0 | 1 | 518 | 19 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324878.1 | 0 | 13 | 518 | 1 | 504 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002515478.1 | 0 | 1 | 519 | 3 | 523 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000002 | 77 | 414 | 75 | 409 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vnz_A | 0.0000002 | 77 | 414 | 75 | 409 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vny_A | 0.0000002 | 77 | 414 | 75 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| DT548485 | 284 | 68 | 349 | 0 |
| HO806132 | 311 | 12 | 320 | 0 |
| DT569595 | 278 | 74 | 349 | 0 |
| GO873156 | 324 | 170 | 491 | 0 |
| CX636465 | 272 | 156 | 427 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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