| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_032976m |
| Family | GH29 |
| Protein Properties | Length: 457 Molecular Weight: 51505.5 Isoelectric Point: 5.3222 |
| Chromosome | Chromosome/Scaffold: 04182 Start: 415960 End: 418283 |
| Description | alpha-L-fucosidase 1 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH29 | 121 | 300 | 5.7e-37 |
| GDVIKELALSAKEAGVDLGLYLSPWDRHEVSYGKTLEYKEFYMGQMPELLTRYGEIKEAWLDSAKGEGEKDMDYFFDSWWIGDEAGVADSTCWSLFNRSS VKIGDTDPKYSQEGDPSGHDWVPAECDVSIRPGWFWHASEIPKSAMRLLDIYYKSVGRNCLLLVNVPPNSSGLVSAEDIK | |||
| Full Sequence |
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| Protein Sequence Length: 457 Download |
| MVEGKKICSC SRSFNTISHS FESNFLLFPT ISITRLLFCR PQATPLPILP IPSAPQLQWQ 60 LTSVTLFIHF GPNTLRDSEW GTGEADPSLF NPTSLNTTQW VQVAKDAGFN RVMLTAVLGT 120 GDVIKELALS AKEAGVDLGL YLSPWDRHEV SYGKTLEYKE FYMGQMPELL TRYGEIKEAW 180 LDSAKGEGEK DMDYFFDSWW IGDEAGVADS TCWSLFNRSS VKIGDTDPKY SQEGDPSGHD 240 WVPAECDVSI RPGWFWHASE IPKSAMRLLD IYYKSVGRNC LLLVNVPPNS SGLVSAEDIK 300 NAFLTASSTR GSSNDSVLTP TMSWKKESRH IGLLRRINLI GSSIDLPGPV AFNVLQVQEP 360 IHMARIIEFH LEIEKDGDWK KVMNGTTVGY QRLLQFPTVE SQHLKFVIDK TWADPLVSFW 420 GLYMDTFSSM VNKYDNSSRV ECLSKPDRCN RYMNNSE |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00812 | Alpha_L_fucos | 3.0e-11 | 67 | 300 | 309 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| pfam01120 | Alpha_L_fucos | 6.0e-13 | 66 | 301 | 297 | + Alpha-L-fucosidase. | ||
| COG3669 | COG3669 | 5.0e-34 | 47 | 423 | 439 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004560 | alpha-L-fucosidase activity |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_180377.2 | 0 | 45 | 428 | 31 | 482 | ATFUC1 (alpha-L-fucosidase 1); alpha-L-fucosidase [Arabidopsis thaliana] |
| Swiss-Prot | Q8GW72 | 0 | 45 | 428 | 31 | 482 | FUCO1_ARATH RecName: Full=Alpha-L-fucosidase 1; AltName: Full=Alpha-L-fucoside fucohydrolase; AltName: Full=Alpha-1,3/4-fucosidase; Short=AtFUC1; Flags: Precursor |
| RefSeq | XP_002276131.1 | 0 | 56 | 437 | 54 | 498 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002313533.1 | 0 | 53 | 428 | 15 | 457 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523703.1 | 0 | 53 | 437 | 64 | 516 | alpha-l-fucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ues_B | 0 | 52 | 418 | 19 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3ues_A | 0 | 52 | 418 | 19 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3mo4_B | 0 | 52 | 418 | 21 | 473 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3mo4_A | 0 | 52 | 418 | 21 | 473 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3uet_B | 0 | 52 | 418 | 19 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| DY270181 | 287 | 56 | 297 | 0 |
| DY291901 | 282 | 56 | 292 | 0 |
| DY272403 | 306 | 56 | 316 | 0 |
| FC905625 | 277 | 56 | 287 | 0 |
| DY277939 | 277 | 56 | 287 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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