| Basic Information | |
|---|---|
| Species | Carica papaya |
| Cazyme ID | evm.model.supercontig_35.44 |
| Family | GH89 |
| Protein Properties | Length: 321 Molecular Weight: 36164.2 Isoelectric Point: 6.7113 |
| Chromosome | Chromosome/Scaffold: 35 Start: 821783 End: 827432 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 80 | 251 | 0 |
| RIAGVTAVEVLAGLHWYLKYWCGAHISWEKTGGVQLFSVPKSGSLPSVQDSGVLVQRPVPWNYYQNAVTSSYSFAWWDWKRWEKEIDWMALQGINLPLAF TGQEAIWKKVFEKFNITSSELDDFFGGPAFLAWSRMANLHGWGGPLPQSWFDQQLDLQKKILSRMYELGMTP | |||
| Full Sequence |
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| Protein Sequence Length: 321 Download |
| MDSLFPAIFV LSVFSVFSLA QSSTIGVHHI SSILDIQDRE RASPAVQLAA ARGVLKRLLP 60 SHSFAFEFHL ISKFQLSGHR IAGVTAVEVL AGLHWYLKYW CGAHISWEKT GGVQLFSVPK 120 SGSLPSVQDS GVLVQRPVPW NYYQNAVTSS YSFAWWDWKR WEKEIDWMAL QGINLPLAFT 180 GQEAIWKKVF EKFNITSSEL DDFFGGPAFL AWSRMANLHG WGGPLPQSWF DQQLDLQKKI 240 LSRMYELGMT PGAKLTGGEE VECEQRFCSE KLNGFARCIF WRENRPAGSG RSLDTCATWS 300 NRTMQWEEDE AALAICPQND * |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam12971 | NAGLU_N | 1.0e-17 | 47 | 127 | 91 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
| pfam05089 | NAGLU | 1.0e-66 | 142 | 251 | 110 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN83148.1 | 0 | 20 | 251 | 21 | 271 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI15090.1 | 0 | 20 | 251 | 21 | 271 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002280399.1 | 0 | 20 | 251 | 21 | 271 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 21 | 251 | 25 | 274 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 251 | 1 | 270 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 1e-31 | 81 | 251 | 216 | 380 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 1e-31 | 81 | 251 | 216 | 380 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 1e-31 | 81 | 251 | 216 | 380 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 1e-31 | 81 | 251 | 216 | 380 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 1e-31 | 81 | 251 | 239 | 403 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| FC906443 | 278 | 16 | 273 | 0 |
| DY278644 | 278 | 16 | 273 | 0 |
| FC909669 | 273 | 21 | 273 | 0 |
| DY267221 | 273 | 21 | 273 | 0 |
| CV885914 | 251 | 1 | 226 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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