Basic Information | |
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Species | Carica papaya |
Cazyme ID | evm.model.supercontig_51.106 |
Family | GH79 |
Protein Properties | Length: 531 Molecular Weight: 58991 Isoelectric Point: 6.4383 |
Chromosome | Chromosome/Scaffold: 51 Start: 1068010 End: 1070729 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 38 | 523 | 0 |
DDTFVCATLDWWPKNKCDYDQCPWGQSGIPYLDLNNKILVNSIKAFQPLRLRVGGSLQDQVIYKLGDAAKECKPFATKNGTLFGFSGGCLEMHRWDQLNS FFNKTGAKVTFGINALIGKKKSADENDILWEGDWDSKNAKDFINYTLSKGYNIDSYEFGNELCGTGVSARIEAKQYAKDVVALKKIVQQVYKHEKTQPKV LGPSGFYEETWFNEFLQATGFEVLGGVTHHIYNMGPGVDKELINRIQDPLYLDQIAQTFKDVSKDAAVYASWTGPWVSESGGAYNSGGKDVQQYFVDGFW YIDQLGMTSTFNHKVYCRQALIGGNYALLNTTTFVPNPDYYGALLWHRLMGPNVLRVTHDGSPFLRVYSHCARDKPGISLVLISMSNSIAYDVTVGEDYN LLVGDYVRGTRNRKVGYSIDGRKRREEYHLTPEHGNIQSNVVLLNGTPLKLTDSLEIPPMNPNLVDASLPIHVEPDSIVFVTIRDF |
Full Sequence |
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Protein Sequence Length: 531 Download |
MARLIGVFVI LAWLISGLVA AEDVQVTVQG VTSIAKTDDT FVCATLDWWP KNKCDYDQCP 60 WGQSGIPYLD LNNKILVNSI KAFQPLRLRV GGSLQDQVIY KLGDAAKECK PFATKNGTLF 120 GFSGGCLEMH RWDQLNSFFN KTGAKVTFGI NALIGKKKSA DENDILWEGD WDSKNAKDFI 180 NYTLSKGYNI DSYEFGNELC GTGVSARIEA KQYAKDVVAL KKIVQQVYKH EKTQPKVLGP 240 SGFYEETWFN EFLQATGFEV LGGVTHHIYN MGPGVDKELI NRIQDPLYLD QIAQTFKDVS 300 KDAAVYASWT GPWVSESGGA YNSGGKDVQQ YFVDGFWYID QLGMTSTFNH KVYCRQALIG 360 GNYALLNTTT FVPNPDYYGA LLWHRLMGPN VLRVTHDGSP FLRVYSHCAR DKPGISLVLI 420 SMSNSIAYDV TVGEDYNLLV GDYVRGTRNR KVGYSIDGRK RREEYHLTPE HGNIQSNVVL 480 LNGTPLKLTD SLEIPPMNPN LVDASLPIHV EPDSIVFVTI RDFGAPACAA * 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 9.0e-172 | 21 | 343 | 323 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 4 | 528 | 9 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 4 | 528 | 7 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 3 | 529 | 5 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 21 | 527 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.000000000007 | 52 | 99 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
JK986839 | 285 | 215 | 499 | 0 |
CK266509 | 316 | 82 | 397 | 0 |
GR118344 | 262 | 95 | 356 | 0 |
AJ805815 | 234 | 199 | 432 | 0 |
GR072627 | 273 | 240 | 512 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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