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Basic Information | |
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Species | Carica papaya |
Cazyme ID | evm.model.supercontig_6.275 |
Family | GH38 |
Protein Properties | Length: 1014 Molecular Weight: 114005 Isoelectric Point: 6.8445 |
Chromosome | Chromosome/Scaffold: 6 Start: 2108134 End: 2118385 |
Description | Glycosyl hydrolase family 38 protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH38 | 46 | 357 | 0 |
NVHLVPHSHDDVGWLKTIDQYYVGSNNSIQGACVENVLDSVVESLLRDPNRKFVFAEMAFFERWWVTQSAETQEQVRKLVDAGQLEFVNGGWCMHDEATC HYIDMIDQTTLGHRLLKEHFNKTPRAGWQIDPFGHSAVQAYLLGAELGFDSVHFARIDYQDRAKRKDDKSLEVVWQGSKTFGSSSQIFANAFPVHYSPPK GFHFEVNDDFVPVQDNLLIFDYNVNQRVDDFVSAALTQANVTRTNHIMWTMGDDFQYQYAESWFKQMDKLIHYVNKDGRVNALYSTPSLYTDAKNAAKET WPLKTDDFFPYA |
Full Sequence |
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Protein Sequence Length: 1014 Download |
MAACRLSYNS LVFMFAVIFL CCFNGSVNCR YIKYDTGAGI VPGKLNVHLV PHSHDDVGWL 60 KTIDQYYVGS NNSIQGACVE NVLDSVVESL LRDPNRKFVF AEMAFFERWW VTQSAETQEQ 120 VRKLVDAGQL EFVNGGWCMH DEATCHYIDM IDQTTLGHRL LKEHFNKTPR AGWQIDPFGH 180 SAVQAYLLGA ELGFDSVHFA RIDYQDRAKR KDDKSLEVVW QGSKTFGSSS QIFANAFPVH 240 YSPPKGFHFE VNDDFVPVQD NLLIFDYNVN QRVDDFVSAA LTQANVTRTN HIMWTMGDDF 300 QYQYAESWFK QMDKLIHYVN KDGRVNALYS TPSLYTDAKN AAKETWPLKT DDFFPYADSA 360 NAYWTGFFTS RPALKRYVRL LSGYYLGARQ LEFLVGKKSS GPTTFALGDA LGVAQHHDGI 420 TGTAKQHTTD DYAKRLAIGA KEAEAVVNSA LSCLTNKRSG QKCVASSLTF SQCQLLNISY 480 CPPTEEKILE KKGLVVVAYN PTGWMRTDII RIPVYDANLI IQDSSGHIIE AQYISLDNVT 540 RNLRKFYTKA YVGLPSTPAP KYWLLFQVSV PPLGWNTYFV SKAAGIGSSS NVFFSRMESP 600 RNKVVEIGPG NLKLSFSSAT GQLRRMYNSK TGVDVPIQQS YLWYASSTGD FDDPQASGAY 660 IFRPNGSPPT IVSRSVSLKV VHGPLVDEVH QQFNSWIYQV TRLYKDKEHA EVEYTIGPIP 720 TDDGVGKEVV TRMTANMATD KVFYTDSNGR DFIKRIRDYR SDWPLEVKQP VAGNYYPLNL 780 GMFIMDKKTE FSVLVDRATG GSSIVDGEVE LMLHRRMLFD DSRGVGEALD EIACSGSTCE 840 GLTVRGNYYM SIDKLGAGAR WRRTTGQEVY SPLLLAFTHE SLENWRSSFL TKATAMDTNY 900 SLPLNVALIT LQELDDWSVL LRLAHLYEEG EDVEQSKLAK VELKRMFAGR TIKEVKETSL 960 SSTQEKSEMK KMRWKVEGDS GKESSPTRGG PLDPSTLVVE LGPMEIRSFL LKF* 1020 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01074 | Glyco_hydro_38 | 8.0e-97 | 46 | 357 | 316 | + Glycosyl hydrolases family 38 N-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. | ||
PLN02701 | PLN02701 | 2.0e-109 | 44 | 827 | 869 | + alpha-mannosidase | ||
cd00451 | GH38N_AMII_euk | 8.0e-113 | 45 | 321 | 277 | + N-terminal catalytic domain of eukaryotic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38). The family corresponds to a group of eukaryotic class II alpha-mannosidases (AlphaMII), which contain Golgi alpha-mannosidases II (GMII), the major broad specificity lysosomal alpha-mannosidases (LAM, MAN2B1), the noval core-specific lysosomal alpha 1,6-mannosidases (Epman, MAN2B2), and similar proteins. GMII catalyzes the hydrolysis of the terminal both alpha-1,3-linked and alpha-1,6-linked mannoses from the high-mannose oligosaccharide GlcNAc(Man)5(GlcNAc)2 to yield GlcNAc(Man)3(GlcNAc)2 (GlcNAc, N-acetylglucosmine), which is the committed step of complex N-glycan synthesis. LAM is a broad specificity exoglycosidase hydrolyzing all known alpha 1,2-, alpha 1,3-, and alpha 1,6-mannosidic linkages from numerous high mannose type oligosaccharides. Different from LAM, Epman can efficiently cleave only the alpha 1,6-linked mannose residue from (Man)3GlcNAc, but not (Man)3(GlcNAc)2 or other larger high mannose oligosaccharides, in the core of N-linked glycans. Members in this family are retaining glycosyl hydrolases of family GH38 that employs a two-step mechanism involving the formation of a covalent glycosyl enzyme complex. Two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst. | ||
cd10810 | GH38N_AMII_LAM_like | 1.0e-174 | 45 | 321 | 279 | + N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38). The subfamily is represented by lysosomal alpha-mannosidase (LAM, Man2B1, EC 3.2.1.114), which is a broad specificity exoglycosidase hydrolyzing all known alpha 1,2-, alpha 1,3-, and alpha 1,6-mannosidic linkages from numerous high mannose type oligosaccharides. LAM is expressed in all tissues and in many species. In mammals, the absence of LAM can cause the autosomal recessive disease alpha-mannosidosis. LAM has an acidic pH optimum at 4.0-4.5. It is stimulated by zinc ion and is inhibited by cobalt ion and plant alkaloids, such as swainsonine (SW). LAM catalyzes hydrolysis by a double displacement mechanism in which a glycosyl-enzyme intermediate is formed and hydrolyzed via oxacarbenium ion-like transition states. A carboxylic acid in the active site acts as the catalytic nucleophile in the formation of the covalent intermediate while a second carboxylic acid acts as a general acid catalyst. The same residue is thought to assist in the hydrolysis (deglycosylation) step, this time acting as a general base. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0004559 | alpha-mannosidase activity |
GO:0005975 | carbohydrate metabolic process |
GO:0006013 | mannose metabolic process |
GO:0008270 | zinc ion binding |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | EEC66555.1 | 0 | 34 | 1013 | 27 | 1004 | hypothetical protein OsI_32713 [Oryza sativa Indica Group] |
RefSeq | NP_001064140.1 | 0 | 34 | 1013 | 27 | 1004 | Os10g0140200 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002265360.1 | 0 | 13 | 1013 | 9 | 1006 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002303405.1 | 0 | 8 | 1013 | 11 | 1011 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002464752.1 | 0 | 40 | 1013 | 35 | 1007 | hypothetical protein SORBIDRAFT_01g026390 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 1hxk_A | 0 | 32 | 829 | 38 | 852 | A Chain A, Golgi Alpha-Mannosidase Ii In Complex With Deoxymannojirimicin |
PDB | 1hww_A | 0 | 32 | 829 | 38 | 852 | A Chain A, Golgi Alpha-Mannosidase Ii In Complex With Deoxymannojirimicin |
PDB | 1hty_A | 0 | 32 | 829 | 38 | 852 | A Chain A, Golgi Alpha-Mannosidase Ii |
PDB | 1ps3_A | 0 | 32 | 829 | 68 | 882 | A Chain A, Golgi Alpha-mannosidase Ii In Complex With Kifunensine |
PDB | 3eju_A | 0 | 32 | 829 | 68 | 882 | A Chain A, Golgi Alpha-mannosidase Ii In Complex With Kifunensine |