| Basic Information | |
|---|---|
| Species | Chlamydomonas reinhardtii |
| Cazyme ID | g4741.t1 |
| Family | GT47 |
| Protein Properties | Length: 745 Molecular Weight: 82589.6 Isoelectric Point: 7.5027 |
| Chromosome | Chromosome/Scaffold: 4 Start: 1801454 End: 1814769 |
| Description | exostosin family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 534 | 691 | 7.6e-27 |
| REPCFRPEQDVAIPNYLDTPWLHQMDMAFESLGGGRYKPKPVDRPYLFHFHGFSKPDMAYSGGVRQGLLAMFKNMSRPDVLINKGAGPSFTAKSKFCLAP LGYGWGIRFTQAMFTGCVPVLIQDHIYTYFWDVVPYEKFSIRVSRHNLHRLFDIIEAV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 745 Download |
| MDLDIGRRTL YVCLLTILSL AQCSAKVEPA TPQNKECPPG CTDHGNCNGE SGECECQFGF 60 GGPDCSQRLL PACHLAPEVK GSIPAFGHWM PKNCLCHAQL RKYGCPRPHF EDPYNCPFYQ 120 FWAWNEIPCF LIKDVPDDQQ YTLSPDGPTD PRVVWKKGHY NHTSARSGID PYQLVDAPPP 180 SPYTLPDQST WLPLDKCGDS KCSGRGWCAL APRIDGHPPP QPQCRCLGFY GGDACETPQA 240 EHCFQGCSGR GTCHGGFCHC KPSYWGLACA RSQAYVSDTW LPHPSKLRVY VYSIPEQLAF 300 KKPWHDIPAL VDTMYLAEVS FVDSLLGDGA VLTQNPWEAN LFLINAYTFY FTGNIGYPAR 360 HFSSVFNYVR TKYPFWNLTA GRNHIALATN DRGTCDLYKL QRTQPELSHP IKLVHYGQAG 420 RLSIHSHRTF TIKGQPHEYD PAFDAAVREW RRLALRTQRL HGGSSSAGPV DEEVATEADG 480 GPGGGAGGGG GAGGGGGGGG GEGGRAVNPL ELLGERVRFK GVPGYSLDAI RMEREPCFRP 540 EQDVAIPNYL DTPWLHQMDM AFESLGGGRY KPKPVDRPYL FHFHGFSKPD MAYSGGVRQG 600 LLAMFKNMSR PDVLINKGAG PSFTAKSKFC LAPLGYGWGI RFTQAMFTGC VPVLIQDHIY 660 TYFWDVVPYE KFSIRVSRHN LHRLFDIIEA VTPEQLAELQ QGVADYHQHF SWHGRHGGLA 720 YNNTMTSLHR RLLNMWTALF PGTT* 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd00055 | EGF_Lam | 0.006 | 36 | 67 | 32 | + Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies | ||
| pfam03016 | Exostosin | 4.0e-9 | 283 | 477 | 209 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| pfam03016 | Exostosin | 3.0e-17 | 532 | 691 | 168 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001694919.1 | 0 | 35 | 740 | 11 | 674 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001694987.1 | 0 | 5 | 435 | 11 | 442 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001694987.1 | 0 | 518 | 736 | 462 | 700 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001698722.1 | 0 | 163 | 372 | 1 | 200 | hypothetical protein CHLREDRAFT_95806 [Chlamydomonas reinhardtii] |
| RefSeq | XP_001699926.1 | 0 | 8 | 740 | 140 | 782 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
