| Basic Information | |
|---|---|
| Species | Mimulus guttatus |
| Cazyme ID | mgv1a001508m |
| Family | GH89 |
| Protein Properties | Length: 807 Molecular Weight: 92694.8 Isoelectric Point: 6.3964 |
| Chromosome | Chromosome/Scaffold: 41 Start: 254027 End: 261301 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 98 | 803 | 0 |
| AEIMIKGTTAVEITSGLYWYLKYMCGAHISWEKTGGAQLASVPKPGSLPPVRNEGVMIQRPVPWNYYQNVVTSSYSYVWWDWERWEKEIDWMALQGVNLP LAFTGQESIWQKVFAEFNITKGDLNDFFGGPAFLAWARMGNLHRWGGPLTENWLSEQLKLQKQILSRMVELGMTPVLPSFSGNVPAALKEIFPKANISRL GDWNTVDGDTRWCCTYLLDPSDPLFIEIGEAFIKQQIKEYGDITDIYSCDTFNENTPPTSDPAYISSLGSAVYTTMSKVNKDAVWLMQGWLFYTDSSFWQ PPQMKALLHSVPFGKMIVLDLFADVKPIWKSSSQFYNTPYIWCMLHNFGGNIEMYGVLDAVASGPIDARTSNNSTMIGVGMCMEGIEQNPVVYELMSEMA FRNDSVQLEEWLTTYSRRRYGKSVNEVESAWKILHRTIYNCTDGIANHNKDYIVKFPDWDPSVNNQLEIIQRRKFTGVQQKMRFFIHETMSFLPQPHLWY NNRDSITALKLFIDAGNELAEIPTYRYDLVDLTRQSLSKLANEVYLSAINAFQDKDAKALSFHSLKFLQLIKDIDKLLASDDNFLLGTWLESAKKLSSNA DEKKQYEWNARTQVTMWYDNTKSVQSKLHDYGNKFWSGLLEAYYLPRASMYFTRLSKSLEENEEFKLEEWRKEWIAYSNKWQKSVEIYPLKAQGDALAIA KELYHK | |||
| Full Sequence |
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| Protein Sequence Length: 807 Download |
| MKSYKNLKLL FITISILLLP ICSSSSFQES EVIESLVNRL TTKKPSPSEQ ESAARGVLRR 60 LLPAHLSSFE FEVITKDACG GNSCFQISNY KNSSRNSAEI MIKGTTAVEI TSGLYWYLKY 120 MCGAHISWEK TGGAQLASVP KPGSLPPVRN EGVMIQRPVP WNYYQNVVTS SYSYVWWDWE 180 RWEKEIDWMA LQGVNLPLAF TGQESIWQKV FAEFNITKGD LNDFFGGPAF LAWARMGNLH 240 RWGGPLTENW LSEQLKLQKQ ILSRMVELGM TPVLPSFSGN VPAALKEIFP KANISRLGDW 300 NTVDGDTRWC CTYLLDPSDP LFIEIGEAFI KQQIKEYGDI TDIYSCDTFN ENTPPTSDPA 360 YISSLGSAVY TTMSKVNKDA VWLMQGWLFY TDSSFWQPPQ MKALLHSVPF GKMIVLDLFA 420 DVKPIWKSSS QFYNTPYIWC MLHNFGGNIE MYGVLDAVAS GPIDARTSNN STMIGVGMCM 480 EGIEQNPVVY ELMSEMAFRN DSVQLEEWLT TYSRRRYGKS VNEVESAWKI LHRTIYNCTD 540 GIANHNKDYI VKFPDWDPSV NNQLEIIQRR KFTGVQQKMR FFIHETMSFL PQPHLWYNNR 600 DSITALKLFI DAGNELAEIP TYRYDLVDLT RQSLSKLANE VYLSAINAFQ DKDAKALSFH 660 SLKFLQLIKD IDKLLASDDN FLLGTWLESA KKLSSNADEK KQYEWNARTQ VTMWYDNTKS 720 VQSKLHDYGN KFWSGLLEAY YLPRASMYFT RLSKSLEENE EFKLEEWRKE WIAYSNKWQK 780 SVEIYPLKAQ GDALAIAKEL YHKYFI* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 6.0e-25 | 50 | 148 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 4.0e-94 | 507 | 804 | 298 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 163 | 501 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 6 | 805 | 3 | 810 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 11 | 805 | 69 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 46 | 805 | 52 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| RefSeq | XP_002273084.1 | 0 | 11 | 805 | 4 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 23 | 805 | 19 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 69 | 801 | 190 | 877 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 2vcb_A | 0 | 69 | 801 | 190 | 877 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 2vca_A | 0 | 69 | 801 | 190 | 877 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 2vc9_A | 0 | 69 | 801 | 190 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 69 | 801 | 213 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
