y
Basic Information | |
---|---|
Species | Mimulus guttatus |
Cazyme ID | mgv1a003100m |
Family | GH31 |
Protein Properties | Length: 609 Molecular Weight: 68792 Isoelectric Point: 9.652 |
Chromosome | Chromosome/Scaffold: 140 Start: 346042 End: 348236 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
---|
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH31 | 88 | 445 | 0 |
PIQRLWPGAVNFPDFLNPKTAEWWADEIRRFHALAPVDGLWIDMNEASNFCNGLCTIPQDRICPNGTGPGWICCLDCKNMTKTRWDDPPYKINASGTQVP IGYKTIATSAYHYNGVLEYDAHSLYGFSQSVATHEGLLRLEGKRPFILTRSTFVGSGRYAAHWTGDNKGTWDDLRYSISTMLNFGIFGVPMVGSDICGFY PAPTEELCNRWIELGAFYPFSRDHANFYSPRQELYQWKSVAISARNALGMRYKLLPYLYTLSYEAHITGAPIARPLFFTFTNETKLYGLSKQFLLGKSLM VSPVLHRNKTELKVLFPPGTWYNLFDMTKVVVSKASHYLSLDAPLHVINVHLYQNAII |
Full Sequence |
---|
Protein Sequence Length: 609 Download |
MQMGIPQPIR SRRSCRKLQK GANPTRRNME RRRPHGRPQG LHTQPQKLPP PEALRIPRQN 60 PLPRHEVHRH HRPRDRRQQY LRHLHARPIQ RLWPGAVNFP DFLNPKTAEW WADEIRRFHA 120 LAPVDGLWID MNEASNFCNG LCTIPQDRIC PNGTGPGWIC CLDCKNMTKT RWDDPPYKIN 180 ASGTQVPIGY KTIATSAYHY NGVLEYDAHS LYGFSQSVAT HEGLLRLEGK RPFILTRSTF 240 VGSGRYAAHW TGDNKGTWDD LRYSISTMLN FGIFGVPMVG SDICGFYPAP TEELCNRWIE 300 LGAFYPFSRD HANFYSPRQE LYQWKSVAIS ARNALGMRYK LLPYLYTLSY EAHITGAPIA 360 RPLFFTFTNE TKLYGLSKQF LLGKSLMVSP VLHRNKTELK VLFPPGTWYN LFDMTKVVVS 420 KASHYLSLDA PLHVINVHLY QNAIIPMQRG GLITKEARKT PFTLVVSFPL GAKSGEARGN 480 LFLDDDELPE MKLGNGRSSY IEFYATVSEG AVKVWSGVEE SKFALEKGLI VEKVVVLGLE 540 GIGSAVEVEV DGNTVEGSFG ISSTGHEYHA EKLEEGADKM KNVMVEVKGL ELLVGKKFVI 600 SWKMGTKS* 660 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01055 | Glyco_hydro_31 | 2.0e-17 | 91 | 140 | 50 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 4.0e-22 | 93 | 137 | 45 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06604 | GH31_glucosidase_II_MalA | 1.0e-73 | 91 | 356 | 272 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
cd06602 | GH31_MGAM_SI_GAA | 5.0e-97 | 206 | 374 | 170 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
pfam01055 | Glyco_hydro_31 | 4.0e-111 | 199 | 445 | 251 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAB96077.1 | 0 | 89 | 605 | 409 | 927 | alpha-glucosidase [Solanum tuberosum] |
RefSeq | XP_002282429.1 | 0 | 89 | 606 | 404 | 922 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002311455.1 | 0 | 89 | 605 | 390 | 907 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 89 | 606 | 408 | 926 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 89 | 606 | 410 | 928 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 92 | 540 | 431 | 852 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3w37_A | 0 | 92 | 540 | 431 | 852 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3lpp_D | 0 | 89 | 602 | 431 | 898 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3lpp_C | 0 | 89 | 602 | 431 | 898 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3lpp_B | 0 | 89 | 602 | 431 | 898 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
EST Download unfiltered results here | ||||
---|---|---|---|---|
Hit | Length | Start | End | EValue |
HO795307 | 519 | 89 | 605 | 0 |
GR194088 | 257 | 134 | 390 | 0 |
DY825555 | 303 | 152 | 454 | 0 |
GR137476 | 257 | 253 | 509 | 0 |
HO795307 | 60 | 1 | 60 | 0.001 |
Sequence Alignments (This image is cropped. Click for full image.) |
---|