| Basic Information | |
|---|---|
| Species | Mimulus guttatus |
| Cazyme ID | mgv1a004017m |
| Family | GH79 |
| Protein Properties | Length: 550 Molecular Weight: 60361.4 Isoelectric Point: 7.6141 |
| Chromosome | Chromosome/Scaffold: 213 Start: 159865 End: 163482 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 43 | 543 | 0 |
| DENFVCATLDWWPSAKCDYGNCSWGNASLFNLDLKNVVFLNAVKAFSPLKIRLGGTLQDKVIYQTEDNKQQPCTPFVQNSSRLFGFTEACLPLARWDELN SFFNQSGALVIFGLNALHGKSIQANNVATGPWDSTNAASLIRYTIKKGYNIYGWELGNELSGNGVGVRIDVDPYASDTITLHGLIQDIYSRNNIITKPQI IAPGGFFDYNWFQQFLSKTVGSLDSITHHIYSLGAGSQGNLVEKILNSTVLDNGAGVFRDLNNIVKKSQNPASAWVGEAGGAYNSGRDGVTNTFVFSFWY LDQLGASSTYDTKTYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGKSVLSTSFTGSRKIRAYAHCAKKSQGITLLLINIDGNTTVNAKVDIHGRV VRMQNHSNIHPHHHMPRHHHRRSKGTPLHHNKQVSANNVREEYHLTPLGGDIHSQTVLLNGKKLTVDSSGVIPALDPVTVDSLEPLIVAPYSIVFVHMPN F | |||
| Full Sequence |
|---|
| Protein Sequence Length: 550 Download |
| MSSLVWFLVF VVCGCSFICD VKGSVSVEGT VVIDGESPIA ETDENFVCAT LDWWPSAKCD 60 YGNCSWGNAS LFNLDLKNVV FLNAVKAFSP LKIRLGGTLQ DKVIYQTEDN KQQPCTPFVQ 120 NSSRLFGFTE ACLPLARWDE LNSFFNQSGA LVIFGLNALH GKSIQANNVA TGPWDSTNAA 180 SLIRYTIKKG YNIYGWELGN ELSGNGVGVR IDVDPYASDT ITLHGLIQDI YSRNNIITKP 240 QIIAPGGFFD YNWFQQFLSK TVGSLDSITH HIYSLGAGSQ GNLVEKILNS TVLDNGAGVF 300 RDLNNIVKKS QNPASAWVGE AGGAYNSGRD GVTNTFVFSF WYLDQLGASS TYDTKTYCRQ 360 TLIGGNYGLL NTTTFVPNPD YYSALLWHRL MGKSVLSTSF TGSRKIRAYA HCAKKSQGIT 420 LLLINIDGNT TVNAKVDIHG RVVRMQNHSN IHPHHHMPRH HHRRSKGTPL HHNKQVSANN 480 VREEYHLTPL GGDIHSQTVL LNGKKLTVDS SGVIPALDPV TVDSLEPLIV APYSIVFVHM 540 PNFDVSACM* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 1.0e-177 | 27 | 347 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 1 | 548 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 1 | 548 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 548 | 12 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283260.1 | 0 | 28 | 548 | 37 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 29 | 548 | 1 | 505 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00002 | 141 | 446 | 124 | 422 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 3vnz_A | 0.00002 | 141 | 446 | 124 | 422 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 3vny_A | 0.00002 | 141 | 446 | 124 | 422 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
