y
Basic Information | |
---|---|
Species | Mimulus guttatus |
Cazyme ID | mgv1a004063m |
Family | GH79 |
Protein Properties | Length: 547 Molecular Weight: 60790.9 Isoelectric Point: 8.4842 |
Chromosome | Chromosome/Scaffold: 117 Start: 202181 End: 206172 |
Description | glucuronidase 1 |
View CDS |
External Links |
---|
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH79 | 39 | 540 | 0 |
DANYICATIDWWPQDKCNYDTCPWGSSSAVNLDLSHPFLGNAIQAFKNLRVRVGGSLQDQVMYGVGNSSSPCHPFKKEKGGLFGFSKGCLHMDRWDQLHS FFTKTGVILTFGLNALHGRHHIERGVWGGDWDRHNAYDFINYTLSKGYHVDSWEFGNELSGKGVGASVGPEQYGKDTIRLNTMIDELYSKSNNMKQPIRP SLVAPGGFYDKVWFDKLLQSSGPRVLNVMSHHMYSLGPGNDGNIIKKILNPDHLNKASFVFGNLSSTIQENGPWASAWVGESGGAYNSGARDISNTFVNT FWYLDQLGMAAKYNTKVYCRQSLIGGFYGLLNKTTYIPNPDYYSALLWNRLMGKGVLDVNITASQYLRSYAHCAKQRVGVTVVVINLSNQTMYNVDVQSS NYAKLPSKNQTGTNNKRSFIHGLKESVSWIGNKASDEKVYREEYHLTPEGGNLQSKIMFLNGKPLQLTELGDIPSLLPAVNEVNSPLSVSPYSVKFVVYP NF |
Full Sequence |
---|
Protein Sequence Length: 547 Download |
MGFRASLLVF TAFLPLILGE IYEEARLVVD TSKTVAETDA NYICATIDWW PQDKCNYDTC 60 PWGSSSAVNL DLSHPFLGNA IQAFKNLRVR VGGSLQDQVM YGVGNSSSPC HPFKKEKGGL 120 FGFSKGCLHM DRWDQLHSFF TKTGVILTFG LNALHGRHHI ERGVWGGDWD RHNAYDFINY 180 TLSKGYHVDS WEFGNELSGK GVGASVGPEQ YGKDTIRLNT MIDELYSKSN NMKQPIRPSL 240 VAPGGFYDKV WFDKLLQSSG PRVLNVMSHH MYSLGPGNDG NIIKKILNPD HLNKASFVFG 300 NLSSTIQENG PWASAWVGES GGAYNSGARD ISNTFVNTFW YLDQLGMAAK YNTKVYCRQS 360 LIGGFYGLLN KTTYIPNPDY YSALLWNRLM GKGVLDVNIT ASQYLRSYAH CAKQRVGVTV 420 VVINLSNQTM YNVDVQSSNY AKLPSKNQTG TNNKRSFIHG LKESVSWIGN KASDEKVYRE 480 EYHLTPEGGN LQSKIMFLNG KPLQLTELGD IPSLLPAVNE VNSPLSVSPY SVKFVVYPNF 540 INQGCI* 600 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-177 | 23 | 346 | 324 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 1 | 545 | 1 | 512 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196400.2 | 0 | 1 | 545 | 1 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | NP_200933.2 | 0 | 1 | 545 | 1 | 538 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 1 | 545 | 1 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002514696.1 | 0 | 15 | 545 | 15 | 538 | Heparanase-2, putative [Ricinus communis] |