Basic Information | |
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Species | Mimulus guttatus |
Cazyme ID | mgv1a008019m |
Family | GH79 |
Protein Properties | Length: 388 Molecular Weight: 43112.1 Isoelectric Point: 7.2769 |
Chromosome | Chromosome/Scaffold: 66 Start: 37637 End: 40525 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 1 | 380 | 0 |
MERWDVMNKFFNQTGTKITFGLNALMGRKKLNSNDSLMVGKWDPQNAHDFMKYTASKGYKIDSYELGNELCGSGVAARIEAEQYGKDMIVLKKLVQELYP NPNTQPKILGPAGFYDKQWFDTFLRVSGPNVVDGLTHHIYNLGAGVDPTLINKIQDPNFLDQIAEVYKDISSSIKMYGPWSRAWVGEAGGAYNSGGKDVS HAFVDGFWYLDQLGMTSAFNHKVFCRQALVGGNYGLLNTTTFIPNPDYYGALLWHRLMGKNVLFTSHKGSPYLRVYSHCSKKSAGISLLMINMSNSTTFE VSVVDETNLYNQEYTNLNQREEYHLTPKDGNILSDVLLLNGTPLKLTESFDIPAMNPQLVDSVSPIKVGPDSIVFATLKG |
Full Sequence |
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Protein Sequence Length: 388 Download |
MERWDVMNKF FNQTGTKITF GLNALMGRKK LNSNDSLMVG KWDPQNAHDF MKYTASKGYK 60 IDSYELGNEL CGSGVAARIE AEQYGKDMIV LKKLVQELYP NPNTQPKILG PAGFYDKQWF 120 DTFLRVSGPN VVDGLTHHIY NLGAGVDPTL INKIQDPNFL DQIAEVYKDI SSSIKMYGPW 180 SRAWVGEAGG AYNSGGKDVS HAFVDGFWYL DQLGMTSAFN HKVFCRQALV GGNYGLLNTT 240 TFIPNPDYYG ALLWHRLMGK NVLFTSHKGS PYLRVYSHCS KKSAGISLLM INMSNSTTFE 300 VSVVDETNLY NQEYTNLNQR EEYHLTPKDG NILSDVLLLN GTPLKLTESF DIPAMNPQLV 360 DSVSPIKVGP DSIVFATLKG FKAPACA* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 3.0e-119 | 1 | 214 | 214 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 1 | 387 | 130 | 513 | unnamed protein product [Vitis vinifera] |
EMBL | CBI27258.1 | 0 | 1 | 386 | 132 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 386 | 130 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 387 | 131 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 1 | 385 | 138 | 529 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000002 | 7 | 304 | 124 | 411 | A Chain A, The Structure Of Soybean Peroxidase |
PDB | 3vnz_A | 0.000002 | 7 | 304 | 124 | 411 | A Chain A, The Structure Of Soybean Peroxidase |
PDB | 3vny_A | 0.000002 | 7 | 304 | 124 | 411 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GR072627 | 260 | 111 | 370 | 0 |
GR170095 | 227 | 4 | 230 | 0 |
GR118344 | 227 | 1 | 227 | 0 |
GR115072 | 231 | 158 | 388 | 0 |
GR196104 | 234 | 130 | 363 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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