y
Basic Information | |
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Species | Mimulus guttatus |
Cazyme ID | mgv1a018437m |
Family | GH89 |
Protein Properties | Length: 582 Molecular Weight: 66185.3 Isoelectric Point: 5.0659 |
Chromosome | Chromosome/Scaffold: 346 Start: 83025 End: 88474 |
Description | alpha-N-acetylglucosaminidase family / NAGLU family |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH89 | 67 | 566 | 0 |
TFAWWDWERWEKEIDWMALQGINLPLAFTGQEAIWQKVFQKFNISGSDLSDFFGGPGFLAWSRMGNLHGWGGPLPQSWLDQQLVMQKKILTRMYELGMNP VLPAFSGNVPAALKSVYPSAKITRLGNWFTVSSDTRWCCTYLLDATDPLFVKIGKAFITQQFKEYGRTSHIYNCDTFDENTPPDDDPKYISSLAAAIFRG MESGDDNAVWLMQMVVLDLYAEVKPVWATSQQFYGIPYIWCMLHNFAGNIEMYGIVDSVGSGPVDARLSTNSTMVGVGMSMEGIEQNPIVYDLMSEMSFR EDKVDIKRRYGRLVPYIQEAWNILYRTLYNCTDGLNDKNRDVIMYFPDVDPNSILTSPLLLSPAKHHSYSNHQSLRRTIYELRSDSYTHPHLWYSTSEVI RALKLFIASGDYLSDSNTYKYDLVDLTRQVLAKYANQLFFKVVEAYQLGDLSLVKQLSEKFLGLVEDLDSLLGCHEGFLLGPWLESAKELAQNEEQKKQV |
Full Sequence |
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Protein Sequence Length: 582 Download |
IQDRERAPPS LQISAAYAAV SRLIPSHASS FQFNIVTKEF CGGESCFKLS NYPAVNRSGS 60 PEIVIDTFAW WDWERWEKEI DWMALQGINL PLAFTGQEAI WQKVFQKFNI SGSDLSDFFG 120 GPGFLAWSRM GNLHGWGGPL PQSWLDQQLV MQKKILTRMY ELGMNPVLPA FSGNVPAALK 180 SVYPSAKITR LGNWFTVSSD TRWCCTYLLD ATDPLFVKIG KAFITQQFKE YGRTSHIYNC 240 DTFDENTPPD DDPKYISSLA AAIFRGMESG DDNAVWLMQM VVLDLYAEVK PVWATSQQFY 300 GIPYIWCMLH NFAGNIEMYG IVDSVGSGPV DARLSTNSTM VGVGMSMEGI EQNPIVYDLM 360 SEMSFREDKV DIKRRYGRLV PYIQEAWNIL YRTLYNCTDG LNDKNRDVIM YFPDVDPNSI 420 LTSPLLLSPA KHHSYSNHQS LRRTIYELRS DSYTHPHLWY STSEVIRALK LFIASGDYLS 480 DSNTYKYDLV DLTRQVLAKY ANQLFFKVVE AYQLGDLSLV KQLSEKFLGL VEDLDSLLGC 540 HEGFLLGPWL ESAKELAQNE EQKKQVRLIV QNFEKNSIFE S* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam12971 | NAGLU_N | 0.0001 | 12 | 65 | 54 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
pfam12972 | NAGLU_C | 9.0e-54 | 373 | 576 | 204 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
pfam05089 | NAGLU | 7.0e-164 | 67 | 369 | 329 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | XP_002280399.1 | 9e-19 | 1 | 65 | 37 | 101 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002280399.1 | 0 | 67 | 565 | 172 | 702 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002318632.1 | 6e-17 | 1 | 65 | 40 | 104 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002318632.1 | 0 | 67 | 565 | 175 | 701 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002511461.1 | 0 | 67 | 565 | 171 | 697 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2vcc_A | 0 | 67 | 561 | 281 | 768 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
PDB | 2vcb_A | 0 | 67 | 561 | 281 | 768 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
PDB | 2vca_A | 0 | 67 | 561 | 281 | 768 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
PDB | 2vc9_A | 0 | 67 | 561 | 281 | 768 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
PDB | 4a4a_A | 0 | 67 | 561 | 304 | 791 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GW865336 | 302 | 137 | 404 | 0 |
HO783128 | 357 | 243 | 565 | 0 |
EE606688 | 259 | 75 | 307 | 0 |
FN754065 | 217 | 63 | 279 | 0 |
AU293001 | 210 | 67 | 276 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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