Basic Information | |
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Species | Mimulus guttatus |
Cazyme ID | mgv1a025097m |
Family | GH79 |
Protein Properties | Length: 279 Molecular Weight: 30842.1 Isoelectric Point: 6.5202 |
Chromosome | Chromosome/Scaffold: 156 Start: 1636 End: 5115 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 2 | 274 | 0 |
IITFGLNALNGKTVEEGNTSFGPANATLVAKGSWDYSIAESFIRYTVNKGYNVFAWALGNELGGIAIDLFMDADQYARDTIALRRLVREIYRAKMRAPQI MAPDDLFEPDWFQQYLEKSQGSLNIISQHIYNLGAGFDPDLINKILDPTVLDIAAIPLRNLQNLLKETGTSAVGWVGESGGAYNNGRDGVTNTFVLSFWY LDILGMAATYDTKVFCRQTLVGGYNGLLDTATFLPNPDYYSALLWHRLMGKHVLRTRFEGSTKIRAYAHCAKN |
Full Sequence |
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Protein Sequence Length: 279 Download |
AIITFGLNAL NGKTVEEGNT SFGPANATLV AKGSWDYSIA ESFIRYTVNK GYNVFAWALG 60 NELGGIAIDL FMDADQYARD TIALRRLVRE IYRAKMRAPQ IMAPDDLFEP DWFQQYLEKS 120 QGSLNIISQH IYNLGAGFDP DLINKILDPT VLDIAAIPLR NLQNLLKETG TSAVGWVGES 180 GGAYNNGRDG VTNTFVLSFW YLDILGMAAT YDTKVFCRQT LVGGYNGLLD TATFLPNPDY 240 YSALLWHRLM GKHVLRTRFE GSTKIRAYAH CAKNPVSS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-80 | 1 | 206 | 207 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN81917.1 | 0 | 1 | 274 | 157 | 420 | hypothetical protein [Vitis vinifera] |
EMBL | CBI25561.1 | 0 | 1 | 273 | 150 | 412 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 273 | 161 | 423 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324603.1 | 0 | 1 | 273 | 121 | 383 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002331013.1 | 0 | 1 | 273 | 147 | 409 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000003 | 54 | 259 | 165 | 370 | A Chain A, Nmr Structure Of The Human Doppel Protein Fragment 24-152 |
PDB | 3vnz_A | 0.000003 | 54 | 259 | 165 | 370 | A Chain A, Nmr Structure Of The Human Doppel Protein Fragment 24-152 |
PDB | 3vny_A | 0.000003 | 54 | 259 | 165 | 370 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
CX636465 | 238 | 36 | 273 | 0 |
CX644916 | 238 | 36 | 273 | 0 |
CX640765 | 238 | 36 | 273 | 0 |
BG599750 | 242 | 33 | 274 | 0 |
GE511439 | 242 | 33 | 274 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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