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Basic Information | |
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Species | Fragaria vesca |
Cazyme ID | mrna07353.1-v1.0-hybrid |
Family | GT47 |
Protein Properties | Length: 219 Molecular Weight: 24951.1 Isoelectric Point: 9.581 |
Chromosome | Chromosome/Scaffold: Start: 7376924 End: 7377684 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 1 | 178 | 0 |
MVACHDWGPEVSKSNVYLRRNLIRVLCNANTSGGFNPSRDVSFPEINLPNGKTHGLIGGLSPRVRTVLAFFAGGLHGPIRLLLLELWENKDEDMMVHQYL PKGVDYYKMMRKSKFCLCPSGFEVASPRVVEAIYTGCVPVLISDHYVAPFCDVLNWKSFSVEVSVNDIPNLKRILMSI |
Full Sequence |
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Protein Sequence Length: 219 Download |
MVACHDWGPE VSKSNVYLRR NLIRVLCNAN TSGGFNPSRD VSFPEINLPN GKTHGLIGGL 60 SPRVRTVLAF FAGGLHGPIR LLLLELWENK DEDMMVHQYL PKGVDYYKMM RKSKFCLCPS 120 GFEVASPRVV EAIYTGCVPV LISDHYVAPF CDVLNWKSFS VEVSVNDIPN LKRILMSIST 180 SHYLRMQRRL IQVRKHFEFN SPPKRFDVFH MVYMAQKT* 240 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-47 | 1 | 178 | 189 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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