Basic Information | |
---|---|
Species | Fragaria vesca |
Cazyme ID | mrna08881.1-v1.0-hybrid |
Family | GT47 |
Protein Properties | Length: 497 Molecular Weight: 56948.6 Isoelectric Point: 9.7657 |
Chromosome | Chromosome/Scaffold: 5 Start: 8743972 End: 8747105 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GT47 | 172 | 456 | 0 |
LKVYIYREGSKPIFHVPHLNGIYASEGWFMRFMESNKQFVTRDPEKAHLFYLPYSMRQLELKLYVPGSHQIKPLAIFLRDYVNMIAGKYPFWNRTSGSDH FLVACHDWGPYTLTQHEELANNTIKALCNADTSEGVFVAGKDVSLPETTIKNPRVPLRNIGGLRVSQRPLLAFFAGYMHGRVRPRLLKYWRDKHEDMKIY GPLPSRISRKMSYIHHMKSSKFCICPMGYEVNSPRIIESIYYECVPVIIADNFPPPLSDVLDWSKFSVNVAEKDIPKLREILLAI |
Full Sequence |
---|
Protein Sequence Length: 497 Download |
MTTAGVILQM FLLTDLLDMW PLSLPIAHVS DESLSSIRSL NQTFSEERVK RLQLISTDVP 60 IIPANSSLKL NISVPAMPDI GPVPKGRSRR RNKGGSVDNM PKVLPPPDPP SIHVPYRLQK 120 FIWSLKPNEA LVYAKKEIDH APEVVDDPDL YAPVFRNMSV FKRSYELMEL ILKVYIYREG 180 SKPIFHVPHL NGIYASEGWF MRFMESNKQF VTRDPEKAHL FYLPYSMRQL ELKLYVPGSH 240 QIKPLAIFLR DYVNMIAGKY PFWNRTSGSD HFLVACHDWG PYTLTQHEEL ANNTIKALCN 300 ADTSEGVFVA GKDVSLPETT IKNPRVPLRN IGGLRVSQRP LLAFFAGYMH GRVRPRLLKY 360 WRDKHEDMKI YGPLPSRISR KMSYIHHMKS SKFCICPMGY EVNSPRIIES IYYECVPVII 420 ADNFPPPLSD VLDWSKFSVN VAEKDIPKLR EILLAIPMRR YMAMQTNVKM RMLTSENSFS 480 LIVELIGPRV VTKMQV* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-65 | 172 | 456 | 304 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |