Basic Information | |
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Species | Fragaria vesca |
Cazyme ID | mrna11607.1-v1.0-hybrid |
Family | GT47 |
Protein Properties | Length: 333 Molecular Weight: 38566.8 Isoelectric Point: 9.6905 |
Chromosome | Chromosome/Scaffold: Start: 9185209 End: 9186429 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 3 | 283 | 0 |
KLFRIWPYKEGEPPLFYNGPVNDIYSIEGQFMDELRKSPFAAKDPNEAIAFYLPISVVNIVRYVYRPYTTYSRLRLQNIIEDYIGIMAKRYPYWNRSNGG DHFLVSCHDWAPDVSVGNPKLFKNFVRVLCNANSSEGFQPIRDVSLPEIKIPFGKLGPPLLKHPPENRSIFAFFAGGAHGHVRRLLFQHWKNKDGEIKVH DYLPKTQNYTELMSKSKFCLCPSGYEVASPRVVESIYTGCVPVIISDSYVLPFSDVLDWSKFSIHVSVAKIPELKSILQTI |
Full Sequence |
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Protein Sequence Length: 333 Download |
MEKLFRIWPY KEGEPPLFYN GPVNDIYSIE GQFMDELRKS PFAAKDPNEA IAFYLPISVV 60 NIVRYVYRPY TTYSRLRLQN IIEDYIGIMA KRYPYWNRSN GGDHFLVSCH DWAPDVSVGN 120 PKLFKNFVRV LCNANSSEGF QPIRDVSLPE IKIPFGKLGP PLLKHPPENR SIFAFFAGGA 180 HGHVRRLLFQ HWKNKDGEIK VHDYLPKTQN YTELMSKSKF CLCPSGYEVA SPRVVESIYT 240 GCVPVIISDS YVLPFSDVLD WSKFSIHVSV AKIPELKSIL QTISEHEYVK KQKRVMQVQR 300 HFVLNRPSRP FDMLHMVMHS VWLRRLNLRL LG* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 5.0e-66 | 14 | 283 | 281 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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