| Basic Information | |
|---|---|
| Species | Fragaria vesca |
| Cazyme ID | mrna20066.1-v1.0-hybrid |
| Family | GT65 |
| Protein Properties | Length: 662 Molecular Weight: 75021.9 Isoelectric Point: 8.7797 |
| Chromosome | Chromosome/Scaffold: 3 Start: 7886097 End: 7896203 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GT65 | 145 | 451 | 0 |
| GLNNQKIAFARACLTARLMNRILLMPSLSASLFYKEFELLKPISFDKVFKFDKFNSLCDGYVQLGQYSDLKNQTGAFELQKGSGRRWTPERDLDQLKQHS KGPYDEHETIRIVGKNPFLWHDHWPVKDYAKVFECLVLVDEIMKEADKVVSRIREIGAEQVRRKSESAENSLLVEPVPYVAVHMRIELDWMIHCKNLERR LNITEICSSKEEIMERVGNIVGLKTPVVVYLAVADSLLQDPSILNGWKEGLVPFEKKKLGFDAQYKKFPYLIQSAIDYEVCLRADVFVGNSFSTFSSLIA LDRTQKL | |||
| Full Sequence |
|---|
| Protein Sequence Length: 662 Download |
| MIGAAGQRGV ELRLKHDWIF ARTMRHGLLK VEIGKLDLMG ERLSKMEHID HPKADDGAMM 60 DLSPHCKHFR SLGCNLNSIA CKCVVLVIIA LVVRAVLLPT YSSFNGTEQN KLVLVSNLSF 120 STLSGSTNFG IRKDKFLEVP QIVWGLNNQK IAFARACLTA RLMNRILLMP SLSASLFYKE 180 FELLKPISFD KVFKFDKFNS LCDGYVQLGQ YSDLKNQTGA FELQKGSGRR WTPERDLDQL 240 KQHSKGPYDE HETIRIVGKN PFLWHDHWPV KDYAKVFECL VLVDEIMKEA DKVVSRIREI 300 GAEQVRRKSE SAENSLLVEP VPYVAVHMRI ELDWMIHCKN LERRLNITEI CSSKEEIMER 360 VGNIVGLKTP VVVYLAVADS LLQDPSILNG WKEGLVPFEK KKLGFDAQYK KFPYLIQSAI 420 DYEVCLRADV FVGNSFSTFS SLIALDRTQK LIKMGVNSSC GVDVRYGTDD QMRWYNKGKG 480 VLNPHFSTSN TIKDDRFNDY KMAANLTTSV PGGSASVAVD MVPLVSTLLE GFAIWLECLA 540 CLLALMFGFP FIVIVAQGPS LPSPSIRLSN SFAGRFRLDD WTAAIPSSMF SLFNLKQKSG 600 IYSRSVIGND FADLESHGGG WDFLRENRCF SDLKMVKKWD EWKRRFGYIE AGQFYRYFKK 660 E* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.002 | 136 | 170 | 35 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11302 | O-FucT-1 | 0.0007 | 284 | 447 | 184 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
| cd11299 | O-FucT_plant | 2.0e-14 | 145 | 448 | 332 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 4.0e-24 | 266 | 448 | 187 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 2.0e-39 | 145 | 448 | 337 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3zy6_A | 0.00003 | 322 | 447 | 212 | 344 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3zy5_A | 0.00003 | 322 | 447 | 212 | 344 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3zy4_A | 0.00003 | 322 | 447 | 212 | 344 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3zy3_B | 0.00003 | 322 | 447 | 212 | 344 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3zy3_A | 0.00003 | 322 | 447 | 212 | 344 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
