| Basic Information | |
|---|---|
| Species | Fragaria vesca |
| Cazyme ID | mrna29475.1-v1.0-hybrid |
| Family | GH89 |
| Protein Properties | Length: 765 Molecular Weight: 86415.6 Isoelectric Point: 7.0028 |
| Chromosome | Chromosome/Scaffold: 7 Start: 7995354 End: 8004896 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH89 | 98 | 761 | 0 |
| PEIEIKGTTAVEIASGLHWYLKYFCGAHVSWDKTGGVQLASIPNTGSLPRVKDEGLKVQRPRGDIDSKKGWLNAWDSLIYEGINLPLAFTGQESIWQKVF LDFNISKGDLNDFFGGPAFLAWARMGNLHAWGGPLSQNWLDQQLILQKQILSRMLELGMTPVLPSFSGNVPATLKKIYPSANITRLGDWNTVNGDHRWCC TYLLDPSDPLFVEIGTAFIRRQVEGSCLTVQSTAVSSTVECLVTCDTFNENSPPTNDPAYISSLGAAVYKAMSKGDTDAVWLMQGWLFYSDSAFWKPPQM KALLHSIPFGKMIVLDLFADVKPIWNTSSQFYDTPYIWCLLHNFGGNLEMYGILDAISSGPVDARTSANSTMVGVGMCMEGIEHNPVIYELTSEMAFRSE KVPVKDWLRTYSRRRYGNAVRQVEEAWEILHRTIYNCTDGIADHNTDFIVKFPDWDPSLESDVINALQLFLDAGNDLSGSLTYRYDLVDLTRQVLSKLAN QVYVDAVTAFQKKDVKAYDVNSKKFVQLIKDIEGLLASDDNFLLGTWLESAKKLATSPMEKRQYEWNARTQVTMWYDTTKTNQSQLHDYANKFWSGLLES YYLPRASSYFHYLSKSLRENKDFEVEKWRTEWISFSNNWQAGTELYPVKAKGNALAISRALYKK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 765 Download |
| MSNLKTQFMI LLLVFVPIAV SVKPQQPVEA LLRRLDSKRS SASVQQAAAK ALLFRLLPTH 60 VDSFEFKIVG KNFECQDVCG GHSCFVINNH SPSRRYGPEI EIKGTTAVEI ASGLHWYLKY 120 FCGAHVSWDK TGGVQLASIP NTGSLPRVKD EGLKVQRPRG DIDSKKGWLN AWDSLIYEGI 180 NLPLAFTGQE SIWQKVFLDF NISKGDLNDF FGGPAFLAWA RMGNLHAWGG PLSQNWLDQQ 240 LILQKQILSR MLELGMTPVL PSFSGNVPAT LKKIYPSANI TRLGDWNTVN GDHRWCCTYL 300 LDPSDPLFVE IGTAFIRRQV EGSCLTVQST AVSSTVECLV TCDTFNENSP PTNDPAYISS 360 LGAAVYKAMS KGDTDAVWLM QGWLFYSDSA FWKPPQMKAL LHSIPFGKMI VLDLFADVKP 420 IWNTSSQFYD TPYIWCLLHN FGGNLEMYGI LDAISSGPVD ARTSANSTMV GVGMCMEGIE 480 HNPVIYELTS EMAFRSEKVP VKDWLRTYSR RRYGNAVRQV EEAWEILHRT IYNCTDGIAD 540 HNTDFIVKFP DWDPSLESDV INALQLFLDA GNDLSGSLTY RYDLVDLTRQ VLSKLANQVY 600 VDAVTAFQKK DVKAYDVNSK KFVQLIKDIE GLLASDDNFL LGTWLESAKK LATSPMEKRQ 660 YEWNARTQVT MWYDTTKTNQ SQLHDYANKF WSGLLESYYL PRASSYFHYL SKSLRENKDF 720 EVEKWRTEWI SFSNNWQAGT ELYPVKAKGN ALAISRALYK KYLM* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-17 | 52 | 148 | 97 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 5.0e-107 | 503 | 762 | 272 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 6.0e-146 | 179 | 498 | 320 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 18 | 753 | 142 | 867 | A Chain A, The Structure Of Endoglucanase From Termite, Nasutitermes Takasagoensis, At Ph 2.5. |
| PDB | 2vcb_A | 0 | 18 | 753 | 142 | 867 | A Chain A, The Structure Of Endoglucanase From Termite, Nasutitermes Takasagoensis, At Ph 2.5. |
| PDB | 2vca_A | 0 | 18 | 753 | 142 | 867 | A Chain A, The Structure Of Endoglucanase From Termite, Nasutitermes Takasagoensis, At Ph 2.5. |
| PDB | 2vc9_A | 0 | 18 | 753 | 142 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 18 | 753 | 165 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
