Basic Information | |
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Species | Fragaria vesca |
Cazyme ID | mrna31120.1-v1.0-hybrid |
Family | GT47 |
Protein Properties | Length: 349 Molecular Weight: 40641 Isoelectric Point: 9.2694 |
Chromosome | Chromosome/Scaffold: 1 Start: 2633369 End: 2634573 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 3 | 290 | 0 |
KRFKIWSYKEGERPLVHLGPMYKRKYDMEGYFIDEIEREEIPFRAKHPDEAHMFFLPFSVAFIVDYVYEPIITREEYHPNRLQQIVMDYVTVVAHKYPYW NRTNGADHFMVSCHDWGRKISVGHSELYKNFVRVLCNANTSEGFEPRRDVSLPQVFLQSGEPGPSNLAHQSPRSRRTLAFYAGGAHGLIRAILLHHWKGK DNKVQVYETVPESMNYTALMEHSKFCLCPSGTEVATPRVVEAIYAGCVPVIISDNYTLPLSDVLNWSQFSVNIAVAKIPEIKTILQAI |
Full Sequence |
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Protein Sequence Length: 349 Download |
MIKRFKIWSY KEGERPLVHL GPMYKRKYDM EGYFIDEIER EEIPFRAKHP DEAHMFFLPF 60 SVAFIVDYVY EPIITREEYH PNRLQQIVMD YVTVVAHKYP YWNRTNGADH FMVSCHDWGR 120 KISVGHSELY KNFVRVLCNA NTSEGFEPRR DVSLPQVFLQ SGEPGPSNLA HQSPRSRRTL 180 AFYAGGAHGL IRAILLHHWK GKDNKVQVYE TVPESMNYTA LMEHSKFCLC PSGTEVATPR 240 VVEAIYAGCV PVIISDNYTL PLSDVLNWSQ FSVNIAVAKI PEIKTILQAI PYKEYLKMQR 300 RVLKVQRHFV LNKPAKPFDV IHMILHSVWL RRINIKLLDR DEHINSRV* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-60 | 3 | 290 | 305 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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