Basic Information | |
---|---|
Species | Fragaria vesca |
Cazyme ID | mrna33411.1-v1.0-hybrid |
Family | GT47 |
Protein Properties | Length: 496 Molecular Weight: 56030.4 Isoelectric Point: 6.2413 |
Chromosome | Chromosome/Scaffold: 5 Start: 5862592 End: 5866229 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GT47 | 128 | 423 | 0 |
RLKVFVYELPSKYNKKILQRDPRCLNHMFAAEIYMHRFLLSSPVRTLNPEEADWFYTPVYTTCDLTPNGLPLPFKSPRMMRSAIQLISSNWPYWNHTEGA DHFFVVPHDFAACFHYQEEKAIERGILPLLQRATLVQTFGQRNHVCLKEGSITVPPYAPPQKMQTHLIPEKTPRSIFVYFRGLFYDVGNDPEGGYYARGA RAAVWENFKDNPLFDISTEHPTTYYEDMQRAVFCLCPLGWAPWSPRLVEAVIFGCIPVIIADDIVLPFADAIPWEEIGVFIDEKDVPNLDTILTSI |
Full Sequence |
---|
Protein Sequence Length: 496 Download |
MLSATTQSLV AMCNTFVEEL TSNRTTQNEP PIAKANQNQI DEENLSSGLI VNFISAAQSL 60 KAISHPIVFD VPTLKKNWDR GNMRFWKWVF AGLVCAALVL EIGYGEQART ERISGSAGDV 120 LDDDPVGRLK VFVYELPSKY NKKILQRDPR CLNHMFAAEI YMHRFLLSSP VRTLNPEEAD 180 WFYTPVYTTC DLTPNGLPLP FKSPRMMRSA IQLISSNWPY WNHTEGADHF FVVPHDFAAC 240 FHYQEEKAIE RGILPLLQRA TLVQTFGQRN HVCLKEGSIT VPPYAPPQKM QTHLIPEKTP 300 RSIFVYFRGL FYDVGNDPEG GYYARGARAA VWENFKDNPL FDISTEHPTT YYEDMQRAVF 360 CLCPLGWAPW SPRLVEAVIF GCIPVIIADD IVLPFADAIP WEEIGVFIDE KDVPNLDTIL 420 TSIPPELILR KQRLLANPSM KQAMLFPQPA EPGDAFHQVL NGLARKLPHD PSVYLKPGQK 480 ILNWTAGPVG DLKPW* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 5.0e-80 | 128 | 423 | 304 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |