| Basic Information | |
|---|---|
| Species | Citrus sinensis |
| Cazyme ID | orange1.1g009057m |
| Family | GH89 |
| Protein Properties | Length: 546 Molecular Weight: 62375.3 Isoelectric Point: 4.5252 |
| Chromosome | Chromosome/Scaffold: 00020 Start: 1426653 End: 1433285 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH89 | 7 | 534 | 0 |
| AVLPAFSGNVPAALQNVFPSAKITQLGNWFSVKSDPRWCCTYLLDATDPLFIEIGRAFIEQQLKEYGRTSHIYNCDTFDENTPPVDSPEYISSLGAAIYS GMQSGDSDAVWLMQGWLFSYDPFWRPPQMKALLNSVPLGKLVVLDLFAEVKPIWSTSKQFYGVPYIWCMLHNFAGNIEMYGILDSIAFGPVEARTSENTT MVGVGMSMEGIEQNPVVYDLMSEMAFQHEKVDVKAWINQYSVRRYGRSVPAIQDAWNVLYHTVYNCTDGATDKNRDVIVAFPDVDPSIISVTEGKYQNYG KPVSKEAVLKSETSSYDHPHLWYSTSEVIRALELFIASGNELSASNTYRYDLIDLTRQALAKYANELFLNIIEAYQLNDAHGVFQLSRRFLELVEDMDGL LACHDGFLLGPWLESAKQLAQNEEQEKQYEWNARTQITMWFDNTQEEASLLRDYGNKYWSGLLRDYYGPRAAIYFKYMIESLESGDGFRLKDWRREWIKL TNDWQNGRNVYPVESNGDALITSQWLYN | |||
| Full Sequence |
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| Protein Sequence Length: 546 Download |
| MLLADFAVLP AFSGNVPAAL QNVFPSAKIT QLGNWFSVKS DPRWCCTYLL DATDPLFIEI 60 GRAFIEQQLK EYGRTSHIYN CDTFDENTPP VDSPEYISSL GAAIYSGMQS GDSDAVWLMQ 120 GWLFSYDPFW RPPQMKALLN SVPLGKLVVL DLFAEVKPIW STSKQFYGVP YIWCMLHNFA 180 GNIEMYGILD SIAFGPVEAR TSENTTMVGV GMSMEGIEQN PVVYDLMSEM AFQHEKVDVK 240 AWINQYSVRR YGRSVPAIQD AWNVLYHTVY NCTDGATDKN RDVIVAFPDV DPSIISVTEG 300 KYQNYGKPVS KEAVLKSETS SYDHPHLWYS TSEVIRALEL FIASGNELSA SNTYRYDLID 360 LTRQALAKYA NELFLNIIEA YQLNDAHGVF QLSRRFLELV EDMDGLLACH DGFLLGPWLE 420 SAKQLAQNEE QEKQYEWNAR TQITMWFDNT QEEASLLRDY GNKYWSGLLR DYYGPRAAIY 480 FKYMIESLES GDGFRLKDWR REWIKLTNDW QNGRNVYPVE SNGDALITSQ WLYNKYLQGT 540 GVFDH* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 7.0e-103 | 241 | 536 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 1.0e-106 | 8 | 236 | 229 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 8 | 544 | 272 | 845 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 6 | 538 | 272 | 808 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 8 | 544 | 272 | 812 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 8 | 545 | 275 | 812 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 8 | 545 | 271 | 809 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 8 | 526 | 381 | 866 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 8 | 526 | 381 | 866 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 8 | 526 | 381 | 866 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 8 | 526 | 381 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 8 | 526 | 404 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783128 | 427 | 84 | 503 | 0 |
| GW865336 | 272 | 8 | 279 | 0 |
| HO783455 | 321 | 43 | 359 | 0 |
| HO783455 | 121 | 393 | 513 | 0 |
| EY669974 | 278 | 54 | 325 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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