| Basic Information | |
|---|---|
| Species | Citrus sinensis |
| Cazyme ID | orange1.1g012026m |
| Family | GH89 |
| Protein Properties | Length: 473 Molecular Weight: 53410.7 Isoelectric Point: 4.6094 |
| Chromosome | Chromosome/Scaffold: 00020 Start: 1426653 End: 1433285 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH89 | 1 | 464 | 0 |
| MSNLHGWGGPLPQSWLDQQLVLQKKILVRIYELGMNPVLPAFSGNVPAALQNVFPSAKITQLGNWFSVKSDPRWCCTYLLDATDPLFIEIGRAFIEQQLK EYGRTSHIYNCDTFDENTPPVDSPEYISSLGAAIYSGMQSGDSDAVWLMQGWLFSYDPFWRPPQMKALLNSVPLGKLVVLDLFAEVKPIWSTSKQFYGVP YIWCMLHNFAGNIEMYGILDSIAFGPVEARTSENTTMVGVGMSMEGIEQNPVVYDLMSEMAFQHEKVDVKAWINQYSVRRYGRSVPAIQDAWNVLYHTVY NCTDGATDKNRDVIVAFPDVDPSIISVTEGKYQNYGKPVSKEAVLKSETSSYDHPHLWYSTSEVIRALELFIASGNELSASNTYRYDLIDLTRQALAKYA NELFLNIIEAYQLNDAHGVFQLSRRFLELVEDMDGLLACHDGFLLGPWLESAKQLAQNEEQEKQ | |||
| Full Sequence |
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| Protein Sequence Length: 473 Download |
| MSNLHGWGGP LPQSWLDQQL VLQKKILVRI YELGMNPVLP AFSGNVPAAL QNVFPSAKIT 60 QLGNWFSVKS DPRWCCTYLL DATDPLFIEI GRAFIEQQLK EYGRTSHIYN CDTFDENTPP 120 VDSPEYISSL GAAIYSGMQS GDSDAVWLMQ GWLFSYDPFW RPPQMKALLN SVPLGKLVVL 180 DLFAEVKPIW STSKQFYGVP YIWCMLHNFA GNIEMYGILD SIAFGPVEAR TSENTTMVGV 240 GMSMEGIEQN PVVYDLMSEM AFQHEKVDVK AWINQYSVRR YGRSVPAIQD AWNVLYHTVY 300 NCTDGATDKN RDVIVAFPDV DPSIISVTEG KYQNYGKPVS KEAVLKSETS SYDHPHLWYS 360 TSEVIRALEL FIASGNELSA SNTYRYDLID LTRQALAKYA NELFLNIIEA YQLNDAHGVF 420 QLSRRFLELV EDMDGLLACH DGFLLGPWLE SAKQLAQNEE QEKQVRCPYV SQ* 480 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 8.0e-61 | 271 | 464 | 194 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 5.0e-136 | 1 | 266 | 266 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 1 | 464 | 235 | 735 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 1 | 464 | 237 | 704 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 1 | 464 | 235 | 702 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 1 | 464 | 238 | 701 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 464 | 234 | 697 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 1 | 460 | 344 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 1 | 460 | 344 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 1 | 460 | 344 | 768 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 1 | 460 | 344 | 768 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 1 | 460 | 367 | 791 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| GW865336 | 302 | 8 | 309 | 0 |
| HO783128 | 351 | 114 | 464 | 0 |
| EY669974 | 278 | 84 | 355 | 0 |
| HO783455 | 321 | 73 | 389 | 0 |
| EY669974 | 66 | 293 | 357 | 0.009 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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