y
Basic Information | |
---|---|
Species | Citrus sinensis |
Cazyme ID | orange1.1g041499m |
Family | GH79 |
Protein Properties | Length: 513 Molecular Weight: 57113.8 Isoelectric Point: 7.0133 |
Chromosome | Chromosome/Scaffold: 00003 Start: 3433563 End: 3435947 |
Description | glucuronidase 1 |
View CDS |
External Links |
---|
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH79 | 30 | 506 | 0 |
DDNFVCATIDWWPINKCDYNQCPWGKSGVLNLDLKNKILSNAIKAFQPLRIRVGGSLQDQVLYKVGNSAKKCPHFKLRKDGLFGFSKGCLSMNRWDEIND LFNQTGAMMTFGLNALIGRKKSKTDDTLWEGDWNAQNARDLMKYTISKGYKIESYELGNELCASGVSAKVSAEQYAKDIVALKNLVREMYPDATTQPKVL GPAGFFDKQWFNTFLEKSGQDVVDGLTHHIYNLGPGNDPELINRIQDPYYLDQIAQTYKDISETVKEFGPWSGAWVGEAGGAFNSGGKYVSHTFADGFWF LDQLGMTSTFNHKVFCRQALIGGNYALLNTTTFIPNPDYYGSLLWHRLMGKNVLATTQNASPYLRVYSHCSKEKPGITVLLINLSNSTSFDVSVINDMNL YPSQEQTQDSQGEKPREEYHLTPEGGNIQSDVVLLNGTPLKLTNSLDIPSMEPKLADRYSPITVAPHSIVFATLRDF |
Full Sequence |
---|
Protein Sequence Length: 513 Download |
LLFCYTTFMH CTGKDVKVTV QGVTSIANTD DNFVCATIDW WPINKCDYNQ CPWGKSGVLN 60 LDLKNKILSN AIKAFQPLRI RVGGSLQDQV LYKVGNSAKK CPHFKLRKDG LFGFSKGCLS 120 MNRWDEINDL FNQTGAMMTF GLNALIGRKK SKTDDTLWEG DWNAQNARDL MKYTISKGYK 180 IESYELGNEL CASGVSAKVS AEQYAKDIVA LKNLVREMYP DATTQPKVLG PAGFFDKQWF 240 NTFLEKSGQD VVDGLTHHIY NLGPGNDPEL INRIQDPYYL DQIAQTYKDI SETVKEFGPW 300 SGAWVGEAGG AFNSGGKYVS HTFADGFWFL DQLGMTSTFN HKVFCRQALI GGNYALLNTT 360 TFIPNPDYYG SLLWHRLMGK NVLATTQNAS PYLRVYSHCS KEKPGITVLL INLSNSTSFD 420 VSVINDMNLY PSQEQTQDSQ GEKPREEYHL TPEGGNIQSD VVLLNGTPLK LTNSLDIPSM 480 EPKLADRYSP ITVAPHSIVF ATLRDFKAPA CA* 540 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 13 | 334 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 511 | 13 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 511 | 11 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 3 | 512 | 15 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 16 | 510 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00000000000004 | 44 | 91 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000002 | 80 | 397 | 75 | 383 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 3vnz_A | 0.000002 | 80 | 397 | 75 | 383 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 3vny_A | 0.000002 | 80 | 397 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
---|---|---|---|---|
Hit | Length | Start | End | EValue |
JK986839 | 278 | 206 | 483 | 0 |
GR118344 | 261 | 87 | 347 | 0 |
GR072627 | 265 | 231 | 495 | 0 |
AJ805815 | 236 | 190 | 425 | 0 |
GO873410 | 322 | 29 | 350 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
---|