y
Basic Information | |
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Species | Prunus persica |
Cazyme ID | ppa001168m |
Family | GH31 |
Protein Properties | Length: 891 Molecular Weight: 98362.9 Isoelectric Point: 6.0265 |
Chromosome | Chromosome/Scaffold: 1 Start: 29179382 End: 29184150 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 236 | 727 | 0 |
FYFFAGPTPLGVVDQYTSFVGRPAPMPYWSLGFHQCRWGYHNLSVVEDVVENYKKAKIPLDVIWNDDDHMDGHKDFTLNPKNYPRPKLLAFLDKIHSIGM KYIVIIDPGIGVNTSYGVYQRGLANDVFIKYEGEPFLAQVWPGAVNFPDFLNPKTVSWWGDEIRRFHELVPVDGLWIDMNEASNFCSGKCKIPKGQCPTG SGPGWVCCLDCKNITKTRWDEPPYKINASGLQVPIGFKTIATSATHYNGVLEYDAHSLYGFSQSIATHKALQGLEGKRPFILTRSTYVGSGRYAAHWTGD NKGTWEDLKISITTVLNFGIFGVPMVGADICGFYPAPTEELCNRWIEVGAFYPFSRDHANFYSPRQELYQWESVAESARNALGMRYKLLPYLYTLNYEAH ISGAPIARPLFFSFPTYTETYGLSTQFLLGSSVMISPVLEQGKSKVKALFPPGTWYSLFDLTQVINSKQGKYVTLDAPLHVVNVHVYQNTIL |
Full Sequence |
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Protein Sequence Length: 891 Download |
MCSLCLSSLL LVLLVLCFSG VSSADTAVNP TIKGKGYRLV SIEETPDGGL LGHLQLIQNS 60 KVYGPDIPLL QLYVKHETQD RKKPITVSEY SGSELIFNYI SDPFGFAVKR KSDGQVLFNS 120 SSDPKDPYGE LVFKDQYLEI STSLPKDASL YGLGENSQPH GIKLYPNDPY TLFTTDVSAI 180 NLNTDLYGSH PVYMDLRNVG GQAYAHSVLL LNSNGMDVFY RGTSLTYKVI GGVFDFYFFA 240 GPTPLGVVDQ YTSFVGRPAP MPYWSLGFHQ CRWGYHNLSV VEDVVENYKK AKIPLDVIWN 300 DDDHMDGHKD FTLNPKNYPR PKLLAFLDKI HSIGMKYIVI IDPGIGVNTS YGVYQRGLAN 360 DVFIKYEGEP FLAQVWPGAV NFPDFLNPKT VSWWGDEIRR FHELVPVDGL WIDMNEASNF 420 CSGKCKIPKG QCPTGSGPGW VCCLDCKNIT KTRWDEPPYK INASGLQVPI GFKTIATSAT 480 HYNGVLEYDA HSLYGFSQSI ATHKALQGLE GKRPFILTRS TYVGSGRYAA HWTGDNKGTW 540 EDLKISITTV LNFGIFGVPM VGADICGFYP APTEELCNRW IEVGAFYPFS RDHANFYSPR 600 QELYQWESVA ESARNALGMR YKLLPYLYTL NYEAHISGAP IARPLFFSFP TYTETYGLST 660 QFLLGSSVMI SPVLEQGKSK VKALFPPGTW YSLFDLTQVI NSKQGKYVTL DAPLHVVNVH 720 VYQNTILPMQ QGGLISKAAR TTPFNLVVTF PAGASNATAK GNLFLDDDEL PEMNLGSGYS 780 TYVDFYATVS QGSVKVWSEV QEGKFALGKG WVVEKVSVLG LDGSGGTSAL EVDGNPVTSV 840 SSIELSVSEQ KYLEEAEDGE TTKSVMVDVN GLSLPVGKNF ALSWKMGIKA * 900 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd06602 | GH31_MGAM_SI_GAA | 1.0e-94 | 488 | 656 | 170 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06603 | GH31_GANC_GANAB_alpha | 3.0e-102 | 256 | 638 | 389 | + This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae. | ||
cd06604 | GH31_glucosidase_II_MalA | 3.0e-124 | 256 | 638 | 389 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
COG1501 | COG1501 | 3.0e-124 | 102 | 803 | 710 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
pfam01055 | Glyco_hydro_31 | 0 | 237 | 727 | 495 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAA10382.2 | 0 | 22 | 888 | 30 | 935 | alpha-D-xylosidase [Tropaeolum majus] |
RefSeq | XP_002282429.1 | 0 | 4 | 888 | 1 | 922 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002311455.1 | 0 | 22 | 888 | 4 | 908 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 17 | 888 | 19 | 926 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 3 | 888 | 5 | 928 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 4 | 821 | 10 | 851 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3w37_A | 0 | 4 | 821 | 10 | 851 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3lpp_D | 0 | 32 | 884 | 76 | 898 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3lpp_C | 0 | 32 | 884 | 76 | 898 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3lpp_B | 0 | 32 | 884 | 76 | 898 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |