| Basic Information | |
|---|---|
| Species | Prunus persica |
| Cazyme ID | ppa001555m |
| Family | GH89 |
| Protein Properties | Length: 804 Molecular Weight: 91640.5 Isoelectric Point: 7.0497 |
| Chromosome | Chromosome/Scaffold: 2 Start: 259489 End: 269322 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 91 | 800 | 0 |
| GPEIQIKGTTAVEIASGLHWYLKYWCGAHVSWDKTGGVQVVSIPKPGSLPRVRDEGLKIQRPIPWNYYQNVVTSSYSFVWWDWERWQKEIDWMALQGINL PLAFTGQESIWQKVFMDFNISKEDLNDFFGGPAFLAWARMGNLHAWGGPLSQNWLDQQLVLQKQILTRMLELGMTPVLPSFSGNVPAALKKIYPSANITR LGDWNTVNGDPRWCCTYLLDPSDTLFVEIGTAFIRRQVEEYGDVTDIYNCDTFNENSPPTNDPAYISSLGAAVYKAMSKGDKDAVWLMQGWLFYSDSSFW KPPQMKALLHSVPFGKMIVLDLFADVKPIWRTSSQFYGTPYIWCLLHNFGGNIEMYGILDAVSSGPVDARTSENSTMVGVGMCMEGIEHNPVIYELTSEM AFRSEKVQVQDWLKTYSRRRYGKTVHQVEAAWEILHHTIYNCTDGIADHNTDFIVKFPDWDPSSNPISNITKQNQMQMLLALDRKRRVLLQETSAHLPQA HLWYSTQEVVNALRLFLDGGNDLSGSLTYRYDLVDLTRQVLSKLANQVYVDAVTAYQGRDVKAYSLHSRNFVQLIKDIDVLLASDDNFLLGTWLESAKKL AANPTERRQYEWNARTQVTMWFDNTKTNQSKLHDYANKFWSGLLGSYYLPRASTYFSYLSKSLRDNKDFEVEEWRKEWISLSNGWQAGTELYPVKAKGDA LAISRALYKK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 804 Download |
| MPNFKTQLLI LILVLVPIVA LSEPEAVEAL LRRLDSKRSP ASVQEAAAKA VLKRLLPTHV 60 DSFDFKIFSK EACGGQSCFL LNNNNLSSRQ GPEIQIKGTT AVEIASGLHW YLKYWCGAHV 120 SWDKTGGVQV VSIPKPGSLP RVRDEGLKIQ RPIPWNYYQN VVTSSYSFVW WDWERWQKEI 180 DWMALQGINL PLAFTGQESI WQKVFMDFNI SKEDLNDFFG GPAFLAWARM GNLHAWGGPL 240 SQNWLDQQLV LQKQILTRML ELGMTPVLPS FSGNVPAALK KIYPSANITR LGDWNTVNGD 300 PRWCCTYLLD PSDTLFVEIG TAFIRRQVEE YGDVTDIYNC DTFNENSPPT NDPAYISSLG 360 AAVYKAMSKG DKDAVWLMQG WLFYSDSSFW KPPQMKALLH SVPFGKMIVL DLFADVKPIW 420 RTSSQFYGTP YIWCLLHNFG GNIEMYGILD AVSSGPVDAR TSENSTMVGV GMCMEGIEHN 480 PVIYELTSEM AFRSEKVQVQ DWLKTYSRRR YGKTVHQVEA AWEILHHTIY NCTDGIADHN 540 TDFIVKFPDW DPSSNPISNI TKQNQMQMLL ALDRKRRVLL QETSAHLPQA HLWYSTQEVV 600 NALRLFLDGG NDLSGSLTYR YDLVDLTRQV LSKLANQVYV DAVTAYQGRD VKAYSLHSRN 660 FVQLIKDIDV LLASDDNFLL GTWLESAKKL AANPTERRQY EWNARTQVTM WFDNTKTNQS 720 KLHDYANKFW SGLLGSYYLP RASTYFSYLS KSLRDNKDFE VEEWRKEWIS LSNGWQAGTE 780 LYPVKAKGDA LAISRALYKK YFS* 840 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-23 | 44 | 142 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-105 | 501 | 801 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 157 | 496 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 6 | 803 | 67 | 868 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 44 | 803 | 56 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 26 | 802 | 27 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 6 | 803 | 2 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 19 | 802 | 21 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 49 | 792 | 175 | 867 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vcb_A | 0 | 49 | 792 | 175 | 867 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vca_A | 0 | 49 | 792 | 175 | 867 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vc9_A | 0 | 49 | 792 | 175 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 49 | 792 | 198 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
