| Basic Information | |
|---|---|
| Species | Prunus persica |
| Cazyme ID | ppa001642m |
| Family | GH89 |
| Protein Properties | Length: 788 Molecular Weight: 89867.9 Isoelectric Point: 5.2738 |
| Chromosome | Chromosome/Scaffold: 5 Start: 15097466 End: 15102740 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 72 | 764 | 0 |
| PQILISGVTGVEILAGLHWYLKHWCGSHISWDKTGGAQLFSVPKAGLLSRVQDAGILVQRPVPWNYYQNAVTSSYSFAWWDWERWEKEIDWMALQGINLP LAFTGQEAIWQKVYLKFNISKSDLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWLDQQLILQKKILVRMYELGMTPVLPAFSGNVPAALKTIYPSAKITRL GNWFSVKSDPRWTCTYLLDATDPLFVEIGRTFIEEQLKEYGRTSHIYNCDTFDENTPPDDDPEYISSLGVAIFRGMQSGDNDGVWLMQGWLFSYDPFWRP PQMKALLQSVPAGRLVVLDLFAEVKPIWITTEQCMLHNFAGNVEMYGVLDAIASGPIDARTSENSTMVGVGMSMEGIEQNPIVYDLMSEMAFQHNKVDAK AWIDQYSARRYGRSVPSIQDAWNILYHTLYNCTDGAYDKNRDVIVAFPDVDPSFISIPPEAFQPNENPVAGRAVLKEITDSFDQPHLWYSTSEVIHALDI FIASGDELSESSAYRYDLVDLTRQALAKYANQLFLKVIEAYQFNDAIGVARRSQKFLGLVEDMDTLLACHDGFLLGPWLESAKKLAQDEEQEKQFEWNAR TQITMWFDNTKEEASLLRDYGNKYWSGLLRDYYGPRAAIYFKYLTQSLEWGSEFRLKDWRREWIKLTNDWQNSRKEFPVKSSGNALNTSRWLF | |||
| Full Sequence |
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| Protein Sequence Length: 788 Download |
| MGIGYISRLL EIQDRERAPS YVQVAAARGV LRRLLPSHSS SFDFQIVSRE QCGGASCFMI 60 KNHPSFRRRG DPQILISGVT GVEILAGLHW YLKHWCGSHI SWDKTGGAQL FSVPKAGLLS 120 RVQDAGILVQ RPVPWNYYQN AVTSSYSFAW WDWERWEKEI DWMALQGINL PLAFTGQEAI 180 WQKVYLKFNI SKSDLDDFFG GPAFLAWSRM GNLHGWGGPL PQSWLDQQLI LQKKILVRMY 240 ELGMTPVLPA FSGNVPAALK TIYPSAKITR LGNWFSVKSD PRWTCTYLLD ATDPLFVEIG 300 RTFIEEQLKE YGRTSHIYNC DTFDENTPPD DDPEYISSLG VAIFRGMQSG DNDGVWLMQG 360 WLFSYDPFWR PPQMKALLQS VPAGRLVVLD LFAEVKPIWI TTEQCMLHNF AGNVEMYGVL 420 DAIASGPIDA RTSENSTMVG VGMSMEGIEQ NPIVYDLMSE MAFQHNKVDA KAWIDQYSAR 480 RYGRSVPSIQ DAWNILYHTL YNCTDGAYDK NRDVIVAFPD VDPSFISIPP EAFQPNENPV 540 AGRAVLKEIT DSFDQPHLWY STSEVIHALD IFIASGDELS ESSAYRYDLV DLTRQALAKY 600 ANQLFLKVIE AYQFNDAIGV ARRSQKFLGL VEDMDTLLAC HDGFLLGPWL ESAKKLAQDE 660 EQEKQFEWNA RTQITMWFDN TKEEASLLRD YGNKYWSGLL RDYYGPRAAI YFKYLTQSLE 720 WGSEFRLKDW RREWIKLTND WQNSRKEFPV KSSGNALNTS RWLFDKYLGS SAENIQSRHG 780 AATEIVI* 840 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-21 | 23 | 103 | 81 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 8.0e-98 | 472 | 767 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 1.0e-171 | 137 | 467 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 1 | 768 | 26 | 838 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 5 | 768 | 32 | 807 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 1 | 768 | 26 | 805 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 1 | 770 | 29 | 806 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 768 | 25 | 800 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 30 | 757 | 178 | 866 | A Chain A, Lip5(mit)2 |
| PDB | 2vcb_A | 0 | 30 | 757 | 178 | 866 | A Chain A, Lip5(mit)2 |
| PDB | 2vca_A | 0 | 30 | 757 | 178 | 866 | A Chain A, Lip5(mit)2 |
| PDB | 2vc9_A | 0 | 30 | 757 | 178 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 30 | 757 | 201 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| HO783128 | 420 | 323 | 734 | 0 |
| DY278644 | 329 | 1 | 329 | 0 |
| DY267221 | 313 | 1 | 313 | 0 |
| GW865336 | 302 | 217 | 510 | 0 |
| DY267221 | 95 | 294 | 386 | 0.000000001 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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