| Basic Information | |
|---|---|
| Species | Prunus persica |
| Cazyme ID | ppa003883m |
| Family | GH79 |
| Protein Properties | Length: 543 Molecular Weight: 60067.3 Isoelectric Point: 8.7349 |
| Chromosome | Chromosome/Scaffold: 7 Start: 21680019 End: 21682739 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 51 | 535 | 0 |
| DDDFICATLDWWPPEKCDYGTCSWVRASFLNLNLSSIILLNAVKAFSPLKLRLGGTLQDKVLYATPDNKQRCVPFQKSTTEMFGFTPGCLPMNRWDELNS FFQKSGAKIIFGLNALTGRTIHSNGTATGAWDYKNSESFIRYSVKKNYTVHGWELGNELCGHGIGTTIGASQYVSDTASLQKIIHDVYKGIEPKPLILSP GGFFDAKWFKDYTDKTTTSLDVVTHHIYNLGPGVDQHLIEKILDPSYLDGIASTFSNLRDILKSSATSAAAWVGEAGGAYNSGRHLVSNSFVFSFWYLDQ LAMSAAYDTKTYCRQTLIGGNYGLLNTTTYEPNPDYYSALLWHRLMGRNVLATSFSGPKKIRAYAHCAKQSKGITVLLINLQNTTTVEARVAFNTSWTLR HKHKSHKSHRAQLKFHQGLRSETVREEYHLTAKDGNLQSQTMLLNGNALTLNSSGIIPNLDPVYVNSSEPILVGPSSIVFAHIPY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 543 Download |
| MGSHFWQMGL YFWVCFSAIS FIHSVNSQGF GGGSIEGTVH VNGKDAIGKI DDDFICATLD 60 WWPPEKCDYG TCSWVRASFL NLNLSSIILL NAVKAFSPLK LRLGGTLQDK VLYATPDNKQ 120 RCVPFQKSTT EMFGFTPGCL PMNRWDELNS FFQKSGAKII FGLNALTGRT IHSNGTATGA 180 WDYKNSESFI RYSVKKNYTV HGWELGNELC GHGIGTTIGA SQYVSDTASL QKIIHDVYKG 240 IEPKPLILSP GGFFDAKWFK DYTDKTTTSL DVVTHHIYNL GPGVDQHLIE KILDPSYLDG 300 IASTFSNLRD ILKSSATSAA AWVGEAGGAY NSGRHLVSNS FVFSFWYLDQ LAMSAAYDTK 360 TYCRQTLIGG NYGLLNTTTY EPNPDYYSAL LWHRLMGRNV LATSFSGPKK IRAYAHCAKQ 420 SKGITVLLIN LQNTTTVEAR VAFNTSWTLR HKHKSHKSHR AQLKFHQGLR SETVREEYHL 480 TAKDGNLQSQ TMLLNGNALT LNSSGIIPNL DPVYVNSSEP ILVGPSSIVF AHIPYVVLPA 540 CR* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 36 | 351 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 1 | 542 | 1 | 555 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 542 | 1 | 533 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 542 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 37 | 541 | 1 | 505 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533671.1 | 0 | 1 | 542 | 1 | 551 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000001 | 106 | 406 | 94 | 371 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vnz_A | 0.000001 | 106 | 406 | 94 | 371 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vny_A | 0.000001 | 106 | 406 | 94 | 371 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
