Basic Information | |
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Species | Prunus persica |
Cazyme ID | ppa019445m |
Family | GH79 |
Protein Properties | Length: 512 Molecular Weight: 55417.8 Isoelectric Point: 8.3257 |
Chromosome | Chromosome/Scaffold: 1 Start: 39353901 End: 39356894 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 28 | 504 | 0 |
DDDFVCATIDWWPPQKCDYGTCSWGSASLLNLDLDNAILLNAIKAFSPLKIRLGGTLQDKVIYQTEESQQPSTSFLKDGSELFGFTQGYLPMSRWDQLNI FFKKTGAVVIFGLNALRGRTISSQGAAVGAWNSSNAESLIRYTVKKGYRIHGWELGNELSGNGVGTRVAAGQYASDTKSLQSIVQNVYAGFEAKPQVLAP GGFFDENWFTEFIHKTPQSLQVVTHHIYNLGPGSAGDLIQKILDPSVLDGISQTFKSLQSLLEKSNTPAVAWVGESGGAYNSGHNLVTNAFVFSFWYLDQ LGMSASYDTKTYCRQTLIGGNYGLLDTNTFVPNPDYYSALLWHRLMGNKVLSTSFPGTKKLRAYAHCSKKTQGITVLLINLDSNTKVQVRVSTESPGKLS YLNFQGLRGSKASQNVREEYHLTAKDGDLHSKVMLLNGKALSVDSSGNIPALEPITVGSSNPTTVAPLSIVFVHIPG |
Full Sequence |
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Protein Sequence Length: 512 Download |
LKSSISVASQ STEGTLFVNG TAAIGFIDDD FVCATIDWWP PQKCDYGTCS WGSASLLNLD 60 LDNAILLNAI KAFSPLKIRL GGTLQDKVIY QTEESQQPST SFLKDGSELF GFTQGYLPMS 120 RWDQLNIFFK KTGAVVIFGL NALRGRTISS QGAAVGAWNS SNAESLIRYT VKKGYRIHGW 180 ELGNELSGNG VGTRVAAGQY ASDTKSLQSI VQNVYAGFEA KPQVLAPGGF FDENWFTEFI 240 HKTPQSLQVV THHIYNLGPG SAGDLIQKIL DPSVLDGISQ TFKSLQSLLE KSNTPAVAWV 300 GESGGAYNSG HNLVTNAFVF SFWYLDQLGM SASYDTKTYC RQTLIGGNYG LLDTNTFVPN 360 PDYYSALLWH RLMGNKVLST SFPGTKKLRA YAHCSKKTQG ITVLLINLDS NTKVQVRVST 420 ESPGKLSYLN FQGLRGSKAS QNVREEYHLT AKDGDLHSKV MLLNGKALSV DSSGNIPALE 480 PITVGSSNPT TVAPLSIVFV HIPGITVPAC K* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-173 | 13 | 329 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI25561.1 | 0 | 11 | 511 | 27 | 533 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 11 | 511 | 38 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 2 | 511 | 19 | 546 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324878.1 | 0 | 14 | 510 | 1 | 504 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002515478.1 | 0 | 2 | 510 | 3 | 522 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000004 | 123 | 419 | 122 | 409 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vnz_A | 0.000004 | 123 | 419 | 122 | 409 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vny_A | 0.000004 | 123 | 419 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DT548485 | 282 | 71 | 352 | 0 |
DT569595 | 278 | 75 | 352 | 0 |
CO091102 | 279 | 82 | 360 | 0 |
HO799886 | 314 | 199 | 512 | 0 |
CX636465 | 259 | 161 | 419 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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