Basic Information | |
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Species | Prunus persica |
Cazyme ID | ppa025624m |
Family | GH79 |
Protein Properties | Length: 502 Molecular Weight: 55670.8 Isoelectric Point: 6.5829 |
Chromosome | Chromosome/Scaffold: 1 Start: 27551563 End: 27553819 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 17 | 495 | 0 |
DDNFICATLDWWPTNKCDYNQCPWGKAGIFNLDLDNKILNNAIKAFNPMRIRVGGSLQDQVNYGVGYGVKSCEGFKKQESGLFGFSDACLDRKRWDELND FFNNTKAKITFGLNALQGKQVSPKDKSLRIGDWNPQNSRDLMEYTIAKGYQIDSYELGNELAGSGVAARIESDQYAKDIKKLKEVVTELYPDASKRPKII GPASFYDKKWYENFLQATGPGVVDAVTHHLYNLGAGVDPTLIDRVQNPFFLSEIAQTFYDLSNTIKEFGPWSEAWVGEAGGAYNSGGKDVSHTFANGFWY LDQLGMTSTYSHKVYCRQALIGGNYALLNTTTFIPNPDYYGALLWHRLMGNRVLSTTHLGSPYLRAYSHCSKNQKGITLVLINMSNTTTFDVAVLPDYNL YLGPIRMRKHGHIVGREREEYHLTPEGGNIQSDVVLLNGNPLKLTNSSDIPKMEPKLVDPTSAISVAADSIVFVSIKDF |
Full Sequence |
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Protein Sequence Length: 502 Download |
EYVEVSVGGV TSIASTDDNF ICATLDWWPT NKCDYNQCPW GKAGIFNLDL DNKILNNAIK 60 AFNPMRIRVG GSLQDQVNYG VGYGVKSCEG FKKQESGLFG FSDACLDRKR WDELNDFFNN 120 TKAKITFGLN ALQGKQVSPK DKSLRIGDWN PQNSRDLMEY TIAKGYQIDS YELGNELAGS 180 GVAARIESDQ YAKDIKKLKE VVTELYPDAS KRPKIIGPAS FYDKKWYENF LQATGPGVVD 240 AVTHHLYNLG AGVDPTLIDR VQNPFFLSEI AQTFYDLSNT IKEFGPWSEA WVGEAGGAYN 300 SGGKDVSHTF ANGFWYLDQL GMTSTYSHKV YCRQALIGGN YALLNTTTFI PNPDYYGALL 360 WHRLMGNRVL STTHLGSPYL RAYSHCSKNQ KGITLVLINM SNTTTFDVAV LPDYNLYLGP 420 IRMRKHGHIV GREREEYHLT PEGGNIQSDV VLLNGNPLKL TNSSDIPKME PKLVDPTSAI 480 SVAADSIVFV SIKDFHAPAC A* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-175 | 1 | 321 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 500 | 25 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 500 | 23 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 3 | 501 | 26 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 1 | 499 | 29 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00000000000003 | 30 | 77 | 539 | 586 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000001 | 112 | 410 | 122 | 408 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 3vnz_A | 0.0000001 | 112 | 410 | 122 | 408 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 3vny_A | 0.0000001 | 112 | 410 | 122 | 408 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
JK986839 | 280 | 193 | 472 | 0 |
GR072627 | 263 | 218 | 480 | 0 |
AJ805815 | 235 | 177 | 411 | 0 |
HO797031 | 371 | 153 | 501 | 0 |
GR118344 | 261 | 74 | 334 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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