Basic Information | |
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Species | Thellungiella halophila |
Cazyme ID | Thhalv10018004m |
Family | GT24 |
Protein Properties | Length: 1602 Molecular Weight: 180739 Isoelectric Point: 5.7953 |
Chromosome | Chromosome/Scaffold: 9 Start: 4065911 End: 4076584 |
Description | UDP-glucose:glycoprotein glucosyltransferases;transferases, transferring hexosyl groups;transferases, transferring glycosyl groups |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT24 | 1290 | 1537 | 0 |
INIFSVASGHLYERFLKIMILSVLKNTDRPLKFWFIKNYLSPQFKDVIPHMAQEYNFEYELITYKWPSWLHKQKEKQRIIWAYKILFLDVIFPLSLEKVI FVDADQIIRTDMGELYDMDIKGRPLAYTPFCDNNKEMDGYRFWRQGFWKEHLRGRPYHISALYVVDLVKFRETAAGDNLRVFYETLSKDPNSLSNLDQDL PNYAQHTVPIFSLPQEWLWCESWCGNATKSKARTIDLCNNPMTKEPKL |
Full Sequence |
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Protein Sequence Length: 1602 Download |
MGTNLRSVLC FLLLVFVFFG VNAQNRRPKN VQVAVKAKWQ GTPLLLEAGE LITKESKQLF 60 WEFTDAWLGS DGETGDSDCK SARDCLLKIS QQASTLLAKP VASLFHFSLT LRSASPRLVL 120 YRQLADESLS SFPHGDDSSA DHCCWVDTGS SLFYDVADLL SWLASPPAAG DAVQGPELFD 180 FDHVHFDSKA GSPVVVLYGA VGTGCFRKFH LSLAKAATEG KVTYVVRPVL PSGCEGKTRP 240 CGAIGARDYV SLAGYGVELA LKNMEYKAMD DSAIKKGITL EDPRTEDLSQ DVRGFIFSKI 300 LDRKPELRSE VMAFRDYLLS STVSDTLDVW ELKDLGHQTA QRIVHASDPL QSMQEINQNF 360 PSVVSSLSRM KLNESIKEEI LSNQRMVPPG KALLALNGAL LNIEDMDLYM LMDLAHQELS 420 LADHFSKLKI PDGAIRKLLL TTPLPEPDSY RVDYRSVHVN YLNNLEEDDM YKRWRSNINE 480 ILMPAFPGQL RYIRKNLFHA VYVIDPATAC GLESIDTLRS LYENQLPVRF GVILFSTQLI 540 KRIEDNGGQI PSSDDAQVKE DISTMIIRLF LYIKEHHGIQ TAFQFLGNVN TLRTESADSS 600 EDDIEQQHVD GAFVETILPK VKSPPQEILL KLQQEHTLKE ASEASSVFVF KLGLAKLKCS 660 FLMNGLVFDS IEEETLLNAM NDELPKIQEQ VYYGQIESRT NVLDKLLSEN GLSRYNPQII 720 GGGKNKPRYV SLASSTRRGE AMLNDVIYLH SPETSDDVKY VTHLLAVDVA TKKGMKLLHE 780 GVRYLIGGSK SARLGVLFST SQNADPYSLL FIKLFETTAS SFSHKEKVLY FLDKLCLIYE 840 REYLLKTSVD SASSQMLVDK VLELSEEYGL SSKAYRSCLT ESLDEELFKR LTKVSQFLSW 900 ELGLESDANA IISNGRVIFP VDERTFLGHD LHLLESMEFN QRVKPVQEII EGIEWQGVDP 960 DLLTSKYFSD VFMFVSSAMA TRDRSSESAR FEVLSSEYSA VMLGSENATI HIDAVIDPLS 1020 PTGQKLASLL QVLQKHVQTS MRIVLNPMVI PLWDIPLKNY YRYVLPNTMG PKAFFANMPL 1080 SKTLTMNLDV PEPWLVEPVI AIHDLDNILL ENLGATTTLQ AVFEVESLVL TGHCSEKDHE 1140 APRGLQLILG TKNRPHLVDT LVMANLGYWQ MKVSPGVWYL QLAPGRSSEL YLLKGGTDGS 1200 HDQSSLKRIT IDDLRGKVVH LEVVKKKGKE HEKLLVPADG DDGVKQNNER GSWNSNFLKW 1260 ASGFVGGRQQ SMKGGTKEEH EKGGRHGKTI NIFSVASGHL YERFLKIMIL SVLKNTDRPL 1320 KFWFIKNYLS PQFKDVIPHM AQEYNFEYEL ITYKWPSWLH KQKEKQRIIW AYKILFLDVI 1380 FPLSLEKVIF VDADQIIRTD MGELYDMDIK GRPLAYTPFC DNNKEMDGYR FWRQGFWKEH 1440 LRGRPYHISA LYVVDLVKFR ETAAGDNLRV FYETLSKDPN SLSNLDQDLP NYAQHTVPIF 1500 SLPQEWLWCE SWCGNATKSK ARTIDLCNNP MTKEPKLQGA RRIVTEWPDL DFEARKFTAK 1560 ILGEDIELNE AVAAATDKPN PPPSRDISED SEQDLESKAE L* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01501 | Glyco_transf_8 | 1.0e-5 | 1294 | 1489 | 206 | + Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. | ||
cd04194 | GT8_A4GalT_like | 1.0e-15 | 1290 | 1506 | 227 | + A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. | ||
cd00505 | Glyco_transf_8 | 2.0e-57 | 1290 | 1537 | 257 | + Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+. | ||
pfam06427 | UDP-g_GGTase | 1.0e-74 | 969 | 1165 | 212 | + UDP-glucose:Glycoprotein Glucosyltransferase. The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. | ||
cd06432 | GT8_HUGT1_C_like | 3.0e-177 | 1290 | 1537 | 248 | + The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity. |
Gene Ontology | |
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GO Term | Description |
GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity |
GO:0006486 | protein glycosylation |
GO:0016757 | transferase activity, transferring glycosyl groups |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAG51883.1 | 0 | 3 | 1601 | 5 | 1674 | AC016162_4 putative UDP-glucose:glycoprotein glucosyltransferase; 101200-91134 [Arabidopsis thaliana] |
DDBJ | BAD28382.1 | 0 | 26 | 1579 | 35 | 1614 | putative UDP-glucose:glycoprotein glucosyltransferase [Oryza sativa Japonica Group] |
RefSeq | NP_177278.3 | 0 | 3 | 1601 | 5 | 1613 | EBS1 (EMS-mutagenized bri1 suppressor 1); UDP-glucose:glycoprotein glucosyltransferase/ transferase, transferring glycosyl groups / transferase, transferring hexosyl groups [Arabidopsis thaliana] |
RefSeq | XP_002268972.1 | 0 | 1 | 1601 | 1 | 1611 | PREDICTED: similar to EBS1 (EMS-MUTAGENIZED BRI1 SUPPRESSOR 1); UDP-glucose:glycoprotein glucosyltransferase/ transferase, transferring glycosyl groups / transferase, transferring hexosyl groups [Vitis vinifera] |
RefSeq | XP_002529534.1 | 0 | 1 | 1487 | 1 | 1499 | UDP-glucose glycoprotein:glucosyltransferase, putative [Ricinus communis] |