dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000383_00246

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UBA737;

CAZyme ID

MGYG000000383_00246

CAZy Family

GH2

CAZyme Description

Beta-glucuronidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
589	MGYG000000383_1\|CGC2	67811.39	5.0887

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000383	1702468	MAG	Sweden	Europe

Gene Location

Start: 248748; End: 250517 Strand: +

Full Sequence Download help

MYSFEAIEKH PNPQVYRNDF LCLDGEWGFA FDKDNSGLSE KWQLSNSLPL KICVPFVYQS	60
KKSGIDSAEF CETVWYKRKM KLPESFAGKR TILHFAAVDY ECDVWINGNH AVNHVGGYSS	120
FSTDITELLT DGENDITVRA CDYDFAKETV RGKQLWGKGE FGCWYKRYTG IWQSVWVEAV	180
NPLHIDKFIL KGDVDTNSVS IKAELKGFAL DDKISADIQI MINDTEVATA SMSVHGGYIN	240
EQLSVDYPGS PFRGSEWWSP EHPNLYRMLI TLKKDGEAVD EVQTYFGMRK LETENGKVLL	300
NNLPFYHRSI LNQGYYPEGY ITPESDERII EDIKLIKSMG YNAMRIHQKI ESPRFLYWCD	360
RIGIAVWEEI PSMYQYRELQ AHKIMNEITA IVERDINHPS IFSWVLFNES WGVQQIRFDV	420
QQQNLTKGAY FTVKSMDPTR FAISNDGWQQ TETDLLTIHD YSAYGEEITD RYDNKSCEIG	480
DNPVAGQRRY AFAKGHCYSG QPIMITEYGG ISYATDGGWG YNEKVKTEEE FLNRFASLTH	540
AIRKIPYMTG YCFTQFTDVE NEQNGLVTID REPKADISKI RKINLGALR	589

Enzyme Prediction help

No EC number prediction in MGYG000000383_00246.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH2	14	507	8.4e-99	0.535904255319149

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG3250	LacZ	8.16e-49	23	440	15	427	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
PRK10150	PRK10150	7.74e-41	21	582	13	590	beta-D-glucuronidase; Provisional
PRK10340	ebgA	1.66e-30	49	440	96	470	cryptic beta-D-galactosidase subunit alpha; Reviewed
PRK09525	lacZ	2.92e-24	5	440	42	483	beta-galactosidase.
pfam02837	Glyco_hydro_2_N	1.42e-17	23	175	4	163	Glycosyl hydrolases family 2, sugar binding domain. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AGB19349.1	1.07e-189	7	583	12	585
AIQ29008.1	3.71e-187	7	585	7	587
BBH21730.1	5.08e-187	1	586	1	587
QYK62156.1	9.09e-185	7	586	7	586
QUL57032.1	1.38e-184	7	585	7	587

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7SF2_A	9.51e-77	5	584	24	579	ChainA, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_B Chain B, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_C Chain C, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_D Chain D, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_E Chain E, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_F Chain F, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838]
4JKM_A	2.91e-35	21	582	16	590	CrystalStructure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],4JKM_B Crystal Structure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],6CXS_A Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13],6CXS_B Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13]
6LEM_B	6.88e-32	23	582	13	584	ChainB, Beta-D-glucuronidase [Escherichia coli]
6LEJ_B	6.98e-32	23	582	15	586	ChainB, Beta-D-glucuronidase [Escherichia coli]
6LEG_A	7.02e-32	23	582	16	587	ChainA, Beta-D-glucuronidase [Escherichia coli],6LEG_B Chain B, Beta-D-glucuronidase [Escherichia coli],6LEG_C Chain C, Beta-D-glucuronidase [Escherichia coli],6LEG_D Chain D, Beta-D-glucuronidase [Escherichia coli],6LEL_A Chain A, Beta-D-glucuronidase [Escherichia coli],6LEL_B Chain B, Beta-D-glucuronidase [Escherichia coli]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
T2KPJ7	1.90e-33	75	411	106	432	Putative beta-glucuronidase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_21970 PE=2 SV=1
P05804	3.82e-31	23	582	15	586	Beta-glucuronidase OS=Escherichia coli (strain K12) OX=83333 GN=uidA PE=1 SV=2
P77989	5.41e-29	75	410	59	389	Beta-galactosidase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=lacZ PE=3 SV=2
O77695	2.33e-27	23	582	38	621	Beta-glucuronidase (Fragment) OS=Chlorocebus aethiops OX=9534 GN=GUSB PE=2 SV=1
Q56307	4.37e-27	16	583	35	593	Beta-galactosidase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=lacZ PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000081	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000383_00246.