CAZyme Information: MGYG000003922_00502

Basic Information

• Species: Bacteroides sp014385165
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides sp014385165
• CAZyme ID: MGYG000003922_00502
• CAZy Family: GH2
• CAZyme Description: Beta-galactosidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
598	MGYG000003922_3|CGC3	68306.1	6.4405

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003922	4876803	MAG	China	Asia

• Gene Location: Start: 139681; End: 141477 Strand: -

Full Sequence      

MNKLLTAALLLLLNVWSGFSENLPRPEYPRPQFERTDWINLNGTWTYQFDFGNSGKDRRL
QSAEKFDQNITVPFCPESKLSGVGHTDFINQMWYQRNLSIPAGWEGKKILLHFGAVDYLS
EIFIDGKFINRHFGGSSSYTVDLTRYVKPGQNHNLVVFVKDDQRSGMQTIGKQCNNFFSG
GCSYTRVTGIWQTVWMEAVAPAGLKAVIARPDIDQKQLVILPEFYNESNGTLEVSLMDGQ
KVVANKTVKCGNGSTIVLPIKNVKLWTPETPNLYDIIYRVKDAKGNVIDEVKSYAGMRKV
HTANGLFYLNNEPYFQRLVLDQGYYPDGIWTAPTDEALKQDIALGKAAGFNGARLHQKVF
EERYYYWADKLGYITWGEAASWGVDVNNDLAARNFISEWSEVVVRDRNHPSLVTWTPFNE
TWGGGPDAYVRLITNIYHLTKAMDPTRPINDASGDNHVLTDIWSVHNYTQEKDKLMEQLT
FTEGKEPYRNARDKDYLAVYEGQPYMVDEFGGIPWMDEKNRKNSWGYGGMPADAEAFYAR
LEGQIDALAASENVCGFCYTQLTDVEQEKNGVYYYNRQPKLDMKRIKAIFEKIPSRKH

Enzyme Prediction     

No EC number prediction in MGYG000003922_00502.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	34	593	6.4e-99	0.6170212765957447

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG3250	LacZ	2.78e-37	31	462	6	441	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
PRK10150	PRK10150	8.93e-33	30	449	3	445	beta-D-glucuronidase; Provisional
PRK10340	ebgA	7.43e-30	26	447	56	470	cryptic beta-D-galactosidase subunit alpha; Reviewed
PRK09525	lacZ	7.47e-20	232	462	257	499	beta-galactosidase.
pfam00703	Glyco_hydro_2	3.67e-13	226	298	28	106	Glycosyl hydrolases family 2. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUT73992.1	0.0	1	596	1	596
QTO26863.1	0.0	1	593	1	593
QKH85514.1	0.0	1	593	1	593
QCQ53325.1	0.0	1	593	1	593
QCQ31054.1	0.0	1	593	1	593

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7SF2_A	1.06e-95	26	593	27	582	ChainA, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_B Chain B, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_C Chain C, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_D Chain D, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_E Chain E, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_F Chain F, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838]
3K4A_A	4.50e-31	41	511	17	508	Crystalstructure of selenomethionine substituted E. coli beta-glucuronidase [Escherichia coli K-12],3K4A_B Crystal structure of selenomethionine substituted E. coli beta-glucuronidase [Escherichia coli K-12]
6JZ1_A	1.44e-30	40	580	19	586	Apostructure of b-glucuronidase from Ruminococcus gnavus at 1.7 Angstrom resolution [[Ruminococcus] gnavus],6JZ1_B Apo structure of b-glucuronidase from Ruminococcus gnavus at 1.7 Angstrom resolution [[Ruminococcus] gnavus],6JZ5_A b-glucuronidase from Ruminococcus gnavus in complex with D-glucuronic acid [[Ruminococcus] gnavus],6JZ5_B b-glucuronidase from Ruminococcus gnavus in complex with D-glucuronic acid [[Ruminococcus] gnavus],6JZ6_A b-glucuronidase from Ruminococcus gnavus in complex with C6-substituted uronic isofagomine [[Ruminococcus] gnavus],6JZ6_B b-glucuronidase from Ruminococcus gnavus in complex with C6-substituted uronic isofagomine [[Ruminococcus] gnavus],6JZ7_A b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine [[Ruminococcus] gnavus],6JZ7_B b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine [[Ruminococcus] gnavus],6JZ8_A b-glucuronidase from Ruminococcus gnavus in complex with D-glucaro 1,5-lactone [[Ruminococcus] gnavus],6JZ8_B b-glucuronidase from Ruminococcus gnavus in complex with D-glucaro 1,5-lactone [[Ruminococcus] gnavus]
4JHZ_A	1.44e-30	41	511	17	508	Structureof E. coli beta-Glucuronidase bound with a novel, potent inhibitor 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[(1S,2S,5S)-2,5-dimethoxycyclohexyl]acetamide [Escherichia coli K-12],4JHZ_B Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[(1S,2S,5S)-2,5-dimethoxycyclohexyl]acetamide [Escherichia coli K-12]
3LPF_A	1.46e-30	41	511	17	508	Structureof E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea [Escherichia coli K-12],3LPF_B Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea [Escherichia coli K-12],3LPG_A Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea [Escherichia coli K-12],3LPG_B Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea [Escherichia coli K-12],5CZK_A Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea [Escherichia coli K-12],5CZK_B Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
T2KPJ7	2.85e-32	5	447	29	464	Putative beta-glucuronidase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_21970 PE=2 SV=1
P05804	1.42e-29	41	580	15	578	Beta-glucuronidase OS=Escherichia coli (strain K12) OX=83333 GN=uidA PE=1 SV=2
Q6LL68	3.23e-25	27	462	67	493	Beta-galactosidase OS=Photobacterium profundum (strain SS9) OX=298386 GN=lacZ PE=3 SV=1
P06864	1.00e-24	37	464	70	487	Evolved beta-galactosidase subunit alpha OS=Escherichia coli (strain K12) OX=83333 GN=ebgA PE=1 SV=4
Q56307	2.31e-23	27	596	34	600	Beta-galactosidase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=lacZ PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000227	0.999137	0.000163	0.000159	0.000143	0.000131

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003922_00502.