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CAZyme Information: MGYG000000631_00206

You are here: Home > Sequence: MGYG000000631_00206

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Prevotella sp002299635
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotella; Prevotella sp002299635
CAZyme ID MGYG000000631_00206
CAZy Family GH20
CAZyme Description Beta-hexosaminidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
544 61559.78 6.9472
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000631 2636006 MAG Madagascar Africa
Gene Location Start: 38939;  End: 40573  Strand: +

Full Sequence      Download help

MFRRIILTMV  LLASLSLSAK  NQDTGSWRIV  PLPQEVRETG  GKPFQITAKT  TILYAAGDEK60
QRKDAEFLSA  HIKEVTGIEA  KTTVKPSKSQ  IRLVLNAGDD  KSEAYSILAG  KSGVTVSATS120
HVGLFRGIES  IMKALPITEG  ENAKSVLLPA  VQLKDSPRFA  YRAFMIDVGR  HYFSVPYLKK180
LIDVFAMHNI  NYFHWHLTED  QGWRLEIKKY  PMLTKIGSVR  KQTVVQGSKD  AFDGVPVSGY240
YTQEEAREIV  KYAADRYITV  IPEIDMPGHM  LAALASYPEL  GCTGGPYEVA  CRFGVFEDVL300
CAGKAETLRF  AKDVIDEVMD  IFPSEYIHIG  GDECPKDRWK  ACANCQKKIA  ELGIQELPGH360
SKEEQLQTWF  MGEIEKEIRC  HGRKMMGWDE  ILEGTPAKDI  TVCGWTSREA  SVRSAREGHP420
TIVAPITNFY  FSNPRINKIE  GIPSIQRVYD  FDPCSDKLTP  TEQRNIIGAE  GCIWTEWVKD480
AEKMEWEMLP  RLAALSEVQW  TAKDKRDLES  FYPRLLHMQD  LYRLYGLNYK  ADIEKAVKEH540
LNKQ544

Enzyme Prediction      help

No EC number prediction in MGYG000000631_00206.

CAZyme Signature Domains help

Created with Snap275481108136163190217244272299326353380408435462489516154502GH20
Family Start End Evalue family coverage
GH20 154 502 1.7e-111 0.973293768545994

CDD Domains      download full data without filtering help

Created with Snap275481108136163190217244272299326353380408435462489516159515GH20_chitobiase-like159502Glyco_hydro_2029532Chb159515GH20_chitobiase-like_1159515GH20_SpHex_like
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06563 GH20_chitobiase-like 0.0 159 515 1 357
The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
pfam00728 Glyco_hydro_20 8.05e-144 159 502 1 345
Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold.
COG3525 Chb 1.46e-104 29 532 136 645
N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].
cd06570 GH20_chitobiase-like_1 3.55e-96 159 515 1 311
A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This subgroup lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
cd06568 GH20_SpHex_like 1.49e-88 159 515 1 329
A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases.

CAZyme Hits      help

Created with Snap2754811081361631902172442722993263533804084354624895166535EFC71905.1|GH209536QRO23734.1|GH2011534QCQ31431.1|GH2011534QDM08718.1|GH2025536QUU03707.1|GH20
Hit ID E-Value Query Start Query End Hit Start Hit End
EFC71905.1 2.65e-248 6 535 8 535
QRO23734.1 3.39e-226 9 536 14 541
QCQ31431.1 2.21e-221 11 534 13 540
QDM08718.1 2.54e-221 11 534 13 540
QUU03707.1 1.62e-207 25 536 30 542

PDB Hits      download full data without filtering help

Created with Snap275481108136163190217244272299326353380408435462489516225336Q63_A665357DUP_A665357DVB_A1035307CBN_A215153RCN_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
6Q63_A 1.99e-167 22 533 24 540
BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron]
7DUP_A 5.40e-104 66 535 43 526
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_A Chain A, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]
7DVB_A 3.00e-103 66 535 43 526
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_C Chain C, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_D Chain D, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]
7CBN_A 1.08e-93 103 530 78 511
Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835]
3RCN_A 1.35e-92 21 515 2 498
CrystalStructure of Beta-N-Acetylhexosaminidase from Arthrobacter aurescens [Paenarthrobacter aurescens TC1]

Swiss-Prot Hits      download full data without filtering help

Created with Snap27548110813616319021724427229932635338040843546248951629529sp|P49008|HEXA_PORGI103530sp|B2UQG6|H0868_AKKM823496sp|P96155|HEX1_VIBFU101526sp|B2UP57|H2018_AKKM829531sp|Q7WUL4|HEX20_CELFI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
P49008 1.80e-127 29 529 37 532
Beta-hexosaminidase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=nahA PE=3 SV=2
B2UQG6 7.99e-93 103 530 97 530
Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1
P96155 3.39e-71 23 496 135 601
Beta-hexosaminidase OS=Vibrio furnissii OX=29494 GN=exoI PE=1 SV=1
B2UP57 1.99e-58 101 526 56 474
Beta-hexosaminidase Amuc_2018 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2018 PE=1 SV=1
Q7WUL4 5.83e-57 29 531 6 479
Beta-N-acetylhexosaminidase OS=Cellulomonas fimi OX=1708 GN=hex20 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.001516 0.983894 0.013822 0.000275 0.000241 0.000220

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000631_00206.