CAZyme Information: MGYG000000088_00110

Basic Information

• Species: Streptococcus lutetiensis
• Lineage: Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus lutetiensis
• CAZyme ID: MGYG000000088_00110
• CAZy Family: GH25
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1065	MGYG000000088_1|CGC1	116957.11	4.887

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000088	1947463	Isolate	United Kingdom	Europe

• Gene Location: Start: 100613; End: 103810 Strand: -

Full Sequence      

MKKNILRSCLVSPIIIGAFLSSGQVFAEENTTTQSTTVTENVQSSVEQSGSLQLNSDSVI
FDDNETNNSLPSSEVQNETQNLSDADKQDSAIANGQEAEKNADDQISLINPSISEDSKET
AGNSKENNVDDSAVQESQSSDDTTDRVSDKTSLSNLAESKVSTSAVQAASQKVTNQLAAS
KAVVKEVTSATLTNKGFDIQYNQAIPAGAKIMFAVWSEVNGQDDLIWYTADSNGHVVAKY
TGSYGKYNIHTYQNLNGQMIGLNGRTIDVPKPSAKVTITKVSGTTYKVTVSDIPAYITSI
QLPTWTEKGGQDDIQWYATTQNVDGTFTRTFSVAEHNLESGKYNVHVYGTSAVTNSLTGL
TGTSFQGDYQFGDVKVQPTLTANGIQISMPSDVSSDMTAYHAVWSAKNDQDDLIWYKVPA
NGQLTAKYTGDYGTYLIHTYAVIKGQMTCISATSIDVPKPSAKAKITKESSTTYKVTITD
VPVYIDSIQVPTWTEKNGQDDIQWYKATKAADGSYYVIFSEATHNLEAGTYNVHVYGNSR
VTNSQTALLGTRFESDYQFGDVKVQASLGQNGINISMPSDVSPNLKVMHAVWSVKNDQDD
LIWYQVPENGQLTAKYTGDYGTYLIHTYAVINGQMTCISATSINVPKPEIKATITKESDV
KVKVTVSNVPVYVTGIKIPVWTSLNGQDDIKWYQATKQFDGIYILTFSPKEHNFESGHYN
IHIYGQSQVNYSLEALSSTSGVDLSTDKYVVDPAVSVQNHDANNGTLKVRIAESEYTKKI
KSVSVAVWSESDQSNLHWYTTSDVYDGVVTVMVNEKNHGYIKGNYTVHVYVDFTDNTTSG
FNLGQYALNADEPAQHAPSYFIDISSHNGVISVSDYQRLKSQGITGVVVKLTEGTSYTNP
YARAQIANAQAAGLRVSAYHYSHYETAAEARAEAQYFVRVAQSMGLSGSTTMVNDMEERS
MLNGDLNANTQVWKDEMNHLGYSNNVYYTMASWLDTKGGKLNTAKFGLSNLWVAHYLYAY
TYLDQESAKSLSYYSNTAAWQYTSVSPKLLHALDESIDYTGRFTW

Enzyme Prediction     

EC	3.2.1.17

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH25	862	1044	2.8e-41	0.9548022598870056

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06522	GH25_AtlA-like	1.15e-65	859	1059	1	192	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.
pfam01183	Glyco_hydro_25	1.66e-38	862	1047	1	176	Glycosyl hydrolases family 25.
cd00599	GH25_muramidase	7.21e-28	860	1044	1	170	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.
pfam08481	GBS_Bsp-like	9.27e-23	757	844	1	89	GBS Bsp-like repeat. This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.
pfam08481	GBS_Bsp-like	2.84e-22	276	363	1	89	GBS Bsp-like repeat. This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VEB82330.1	0.0	1	1065	1	1065
VTT01130.1	0.0	1	1065	1	1065
SQG57101.1	0.0	1	1065	1	1065
QIM45577.1	0.0	1	1065	16	1080
QGZ27451.1	0.0	1	1065	16	1081

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1JFX_A	2.07e-06	862	1016	8	165	Crystalstructure of the bacterial lysozyme from Streptomyces coelicolor at 1.65 A resolution [Streptomyces coelicolor]

Swiss-Prot Hits     

has no Swissprot hit.

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000354	0.998823	0.000300	0.000185	0.000166	0.000148

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000088_00110.