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CAZyme Information: MGYG000000246_00024

You are here: Home > Sequence: MGYG000000246_00024

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Streptococcus pasteurianus
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pasteurianus
CAZyme ID MGYG000000246_00024
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
753 MGYG000000246_1|CGC1 87064.71 5.5229
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000246 2159802 Isolate China Asia
Gene Location Start: 21736;  End: 23997  Strand: +

Full Sequence      Download help

MHTDYEMNII  YQSKNQQFHL  FNGEISYIFR  VSGDGKLLHL  YYGETLPDND  YSHLIEMHHR60
PMSTYRNEND  LLYSLEHLRQ  EFPEYGTTDF  RHPAISILQK  NGSRLTDFVY  IGHEIEDGKP120
RLEGLPATYV  DRDSESKTLK  VYLLDAITSI  QVELLYTIYR  DYPVITRSVR  IINKGKESQI180
IENISSLSLD  LPDADYEWQQ  LSGAWGRERT  IKSRTLQQGI  QSIESTRGIS  SHQHNPFVTL240
KRKNTDENQG  EAIGAALVYS  GNFLIQAEVD  TWDVTRLQIG  INPFGFNWQL  NSGETFTTPE300
AILVYSSTGL  NGMSQTFHQL  FRKRLARGEW  REKDRPVLIN  NWEATYFDFD  EDKLVSIAKK360
AFDVGIELFV  LDDGWFGNRE  NDCAGLGDWY  VNPKRLPEGI  SSLSEKIRSF  GMKFGLWFEP420
EMVNKDSELY  RKHPNWIIST  PNRKPHHGRN  QYVLNFGLDE  VVENIFDQMC  KIIDESKLDY480
IKWDMNRPLT  DVFDSHLSAN  QQGEVFHRYI  LGVYRLYEKL  ITKYPNILFE  SCSSGGGRFD540
PGMLYYAPQA  WASDDSDAIE  RLKIQYGTSM  LYPISSIGSH  VSIVPNHQTN  RIVPIKTRGN600
VAFFGAFGYE  LDLNELNEDD  LSIVKEQISF  YKKYRNLIHN  GTFYRLLSPF  DNDNQTSWMV660
VSHDKKIAIV  AHYKTLNEVN  ASYRRLKLKG  LDSNRLYQVE  QNGLYSGAEL  MKAGLVCSDA720
SSGQINDQNQ  RPETFDFDSK  VWVIKQEESD  DEQ753

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap377511215018822526330133837641445148952756460264067771518715GH36
Family Start End Evalue family coverage
GH36 18 715 3.7e-286 0.9941860465116279

CDD Domains      download full data without filtering help

Created with Snap377511215018822526330133837641445148952756460264067771515715GalA295641Melibiase334633GH3635291Glyco_hydro_36N655744Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 15 715 1 665
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 295 641 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 2.92e-145 334 633 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 1.92e-118 35 291 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 5.93e-23 655 744 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap37751121501882252633013383764144514895275646026406777151753SQI09126.1|GH361753QCE37203.1|GH361753BAK30524.1|GH367753QIX75016.1|GH361748CUX97715.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
SQI09126.1 0.0 1 753 1 753
QCE37203.1 0.0 1 753 1 753
BAK30524.1 0.0 1 753 1 753
QIX75016.1 0.0 7 753 1 747
CUX97715.1 0.0 1 748 1 748

PDB Hits      download full data without filtering help

Created with Snap377511215018822526330133837641445148952756460264067771577454FNR_A77454FNQ_A77454FNP_A77454FNU_A77454FNT_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNR_A 2.55e-277 7 745 1 725
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNQ_A 2.07e-276 7 745 1 725
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNP_A 2.38e-275 7 745 1 725
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 2.38e-275 7 745 1 725
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 3.37e-275 7 745 1 725
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap37751121501882252633013383764144514895275646026406777157745sp|Q9ALJ4|AGAA_GEOSE9714sp|G1UB44|MELA_LACAC15714sp|P43467|AGAL1_PEDPE7715sp|G4T4R7|AGASK_RUMGN79747sp|Q2TW69|AGALC_ASPOR
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 1.40e-276 7 745 1 725
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 3.03e-230 9 714 6 711
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.43e-220 15 714 10 710
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 2.65e-205 7 715 1 701
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q2TW69 5.41e-183 79 747 96 751
Probable alpha-galactosidase C OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=aglC PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000052 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000246_00024.