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CAZyme Information: MGYG000001386_00255

You are here: Home > Sequence: MGYG000001386_00255

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Enterocloster clostridioformis
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Enterocloster; Enterocloster clostridioformis
CAZyme ID MGYG000001386_00255
CAZy Family GH36
CAZyme Description Bifunctional alpha-galactosidase/sucrose kinase AgaSK
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
733 MGYG000001386_1|CGC2 82145.55 5.5269
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001386 5455983 Isolate not provided not provided
Gene Location Start: 251601;  End: 253802  Strand: +

Full Sequence      Download help

MAIQYQENGR  IFTLHTDHST  YQMKADSYGN  LLHLYYGDRT  EGSMEYMLTF  EDRGFSPNPY60
EAGDDRTYSL  DALPQEYPHQ  GSGDFRSPAF  AVEQAGRSYG  LNLRYAGYEI  CKGKYSLPGL120
PAMYGEGRED  AESLKIRLTD  QVSGLAVTLL  YGVFPGYDII  TRAVCVENGG  DGPAALKRVY180
SACLDFLHGE  YDLIQFYGRH  AMERNFQRTA  LCHGAQVIGS  RRGTSSHQYN  PFLILAGRET240
TEASGPCYSM  SFVYSGPFKA  EAETDQYGQT  RMAMGLQDEM  FSYELKPGER  FFGPEVIMGY300
SGQGLGALSR  SIHKAMRRSL  CRGKYKTIPR  PVLINNWEAT  YFDFTGEKIL  DIARQAKDLG360
VEMMVLDDGW  FGNRDSDFSG  LGDWQVNVKK  LGGSLGSLVS  RINGLGMKFG  IWVEPEMVSE420
DSCLYREHPD  WAFAVPGRKP  VRGRSQLVLD  FSRKEVADYI  FDSICQVLDS  AHIEYLKWDM480
NRSIADVYSA  ADKTAGGDSP  GSVLYRYMLG  LYDFLERLTK  RYPDLLIEGC  SGGGGRFDAG540
MLYYTPQIWC  SDNTDAVDRI  RIQYGTSFGY  PISAVGSHVS  AVPNHQTGRI  TPMKTRGVVA600
MAGSFGYELN  LNAISDEEKN  CVREQIDAYH  KYWHLIHDGE  YYRLTNPFED  REAAAWLFVR660
EDRGEALLNA  VTLKAHGNPL  TLYVRLEGLE  PGAMYRDEDT  GAVYPGAGLM  SAGIPIPPMT720
GEYQAWQVHL  RRI733

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367310914618321925629332936640343947651354958662365969611715GH36
Family Start End Evalue family coverage
GH36 11 715 2.6e-258 0.997093023255814

CDD Domains      download full data without filtering help

Created with Snap3673109146183219256293329366403439476513549586623659696291639Melibiase12733GalA329631GH3629286Glyco_hydro_36N654730Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam02065 Melibiase 2.49e-179 291 639 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
COG3345 GalA 1.72e-175 12 733 4 687
Alpha-galactosidase [Carbohydrate transport and metabolism].
cd14791 GH36 1.19e-144 329 631 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 3.27e-105 29 286 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 1.61e-24 654 730 2 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36731091461832192562933293664034394765135495866236596961733QIX93423.1|GH361733ANU49477.1|GH361733QQR01604.1|GH361733QJU19082.1|GH361733QRP38527.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QIX93423.1 0.0 1 733 1 733
ANU49477.1 0.0 1 733 1 733
QQR01604.1 0.0 1 733 1 733
QJU19082.1 0.0 1 733 1 733
QRP38527.1 0.0 1 733 1 733

PDB Hits      download full data without filtering help

Created with Snap367310914618321925629332936640343947651354958662365969617272YFN_A17334FNQ_A17334FNR_A17334FNU_A17334FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2YFN_A 0.0 1 727 1 714
galactosidasedomain of alpha-galactosidase-sucrose kinase, AgaSK [[Ruminococcus] gnavus E1],2YFO_A GALACTOSIDASE DOMAIN OF ALPHA-GALACTOSIDASE-SUCROSE KINASE, AGASK, in complex with galactose [[Ruminococcus] gnavus E1]
4FNQ_A 1.35e-233 1 733 1 727
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 2.01e-230 1 733 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 1.84e-228 1 733 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNP_A 1.84e-228 1 733 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36731091461832192562933293664034394765135495866236596961727sp|G4T4R7|AGASK_RUMGN1733sp|Q9ALJ4|AGAA_GEOSE3733sp|G1UB44|MELA_LACAC3733sp|P43467|AGAL1_PEDPE75732sp|Q5AU92|AGALC_EMENI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
G4T4R7 0.0 1 727 1 714
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q9ALJ4 1.10e-229 1 733 1 727
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 2.05e-217 3 733 6 731
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 2.01e-212 3 733 4 730
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
Q5AU92 6.07e-170 75 732 97 749
Alpha-galactosidase C OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=aglC PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000053 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001386_00255.