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CAZyme Information: MGYG000001809_00007
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Eisenbergiella; | |||||||||||
| CAZyme ID | MGYG000001809_00007 | |||||||||||
| CAZy Family | GH36 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 5651; End: 7816 Strand: + | |||||||||||
Full Sequence Download help
| MHIINIEEDR IGLRFGVTKE NRLVLLAVTE GKQRQASPDQ EAPAREDGSE AGNDDAFREY | 60 |
| APLEATVTGA NCPEDRMGNQ LIHTSLAVKL RYERHERRQT EDGAEYVFFL KDEDTGMAAR | 120 |
| LHYRFYEGMN VISCYTEVEN QGRLPQGLEA VTSFSLHGLE RDGNLPYEER FRLHLVHNGW | 180 |
| QKELQWHAYR FSELGLAASQ KPGRYNSTKF ISVTNTGAWS TKQYLPLGIL EDEETGRFLA | 240 |
| WQIEHNGSWN WEIGEHAGQL YLKAAGPTEQ YAHWYKELKP GETFVSVPAA VAYGCGKADE | 300 |
| AVRALTAYRR RIRRENEDNR KMPVIFNDYM NCLWGNPTTE EEIPLIDMAA ACGCEYYCID | 360 |
| CGWYSAGEWW GNVGEWQPSE ERFPKTEAFP EGLKSLLAYI RQKGMVPGLW LELEVMGLNC | 420 |
| PLAKEKPDEW FFMRHGKRVR EKTRYQLDYR NPEVREFATG VIRRLVEDYG VGYIKMDYNI | 480 |
| EPGIGTEQNA DSAGDGLLEH QRAYLSWLDG IFAKYPDLVI ENCGSGGMRM DYAMLKRHSV | 540 |
| QSTSDMEDYR MYATIAVNSP LALTPEQAAV WSYPLNADDA EETIFNMVNV LLLRIHQSGH | 600 |
| LFRLGETCQR LIREAISWYQ ATREDRREAL PFWPLGFGTY YDAWTALGMK GKEKRYIAVW | 660 |
| RRGGEETSCR LSLPDCCGKD IRVRCAYPAD RPVDFAWDAQ KAELTVTFPE AFMARLFEIE | 720 |
| E | 721 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH36 | 83 | 624 | 6.8e-92 | 0.7674418604651163 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd14791 | GH36 | 8.86e-86 | 321 | 621 | 1 | 299 | glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
| pfam02065 | Melibiase | 1.56e-27 | 308 | 565 | 27 | 280 | Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27. |
| COG3345 | GalA | 5.20e-20 | 107 | 576 | 97 | 547 | Alpha-galactosidase [Carbohydrate transport and metabolism]. |
| pfam16875 | Glyco_hydro_36N | 2.98e-04 | 85 | 183 | 69 | 173 | Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold. |
| cd14792 | GH27 | 8.52e-04 | 326 | 491 | 5 | 137 | glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| ADL52223.1 | 7.63e-268 | 1 | 721 | 1 | 702 |
| QBE95776.1 | 1.04e-267 | 60 | 719 | 47 | 700 |
| QIB55801.1 | 2.10e-267 | 60 | 719 | 47 | 700 |
| QMW76333.1 | 2.10e-267 | 60 | 719 | 47 | 700 |
| BCK00066.1 | 2.68e-263 | 1 | 720 | 1 | 701 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2XN0_A | 7.55e-21 | 98 | 531 | 129 | 538 | Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN0_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN1_A Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_C Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_D Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM] |
| 2XN2_A | 2.30e-20 | 98 | 531 | 129 | 538 | Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM with galactose [Lactobacillus acidophilus NCFM] |
| 6JHP_A | 5.62e-17 | 90 | 565 | 133 | 601 | Crystalstructure of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila [Paecilomyces sp. 'thermophila'],6JHP_B Crystal structure of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila [Paecilomyces sp. 'thermophila'],6JHP_C Crystal structure of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila [Paecilomyces sp. 'thermophila'],6JHP_D Crystal structure of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila [Paecilomyces sp. 'thermophila'] |
| 6PHU_A | 2.64e-15 | 214 | 604 | 233 | 653 | SpAgawild type apo structure [Streptococcus pneumoniae TIGR4],6PHV_A Chain A, Alpha-galactosidase [Streptococcus pneumoniae TIGR4] |
| 3MI6_A | 8.00e-15 | 100 | 548 | 127 | 552 | ChainA, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_B Chain B, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_C Chain C, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_D Chain D, Alpha-galactosidase [Levilactobacillus brevis ATCC 367] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| G1UB44 | 4.13e-20 | 98 | 531 | 129 | 538 | Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1 |
| Q9UUZ4 | 9.01e-19 | 101 | 565 | 147 | 590 | Alpha-galactosidase C OS=Aspergillus niger OX=5061 GN=aglC PE=1 SV=1 |
| Q0CEF5 | 1.06e-17 | 101 | 562 | 124 | 563 | Probable alpha-galactosidase G OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=aglG PE=3 SV=1 |
| B8NWY6 | 1.91e-17 | 101 | 565 | 150 | 592 | Probable alpha-galactosidase C OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=aglC PE=3 SV=2 |
| Q2TW69 | 1.91e-17 | 101 | 565 | 150 | 592 | Probable alpha-galactosidase C OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=aglC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000045 | 0.000004 | 0.000001 | 0.000000 | 0.000000 | 0.000000 |