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CAZyme Information: MGYG000002247_00108

You are here: Home > Sequence: MGYG000002247_00108

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Acetatifactor sp900771995
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Acetatifactor; Acetatifactor sp900771995
CAZyme ID MGYG000002247_00108
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
798 MGYG000002247_1|CGC2 90322.86 5.1719
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002247 3138747 MAG Peru South America
Gene Location Start: 109407;  End: 111803  Strand: +

Full Sequence      Download help

MIQIVKDTRP  WFFLQTAHST  YGMRVMETGH  LEHLYYGGQI  TVDETDPSSC  VPLVMQRAFA60
PGNACTYDRE  YPQISLEDVC  LEVGTCGKGD  IREPLLEVRF  ADGSVTSDFT  FASFEVLTFE120
DREQRLQDSG  LPHSYSEAEK  NSAECLQIIL  QDATNHLELQ  LLYTVYADCD  VITRNACLIN180
HSDTNVTVDR  CLSAQLDLTE  DYTTVTHFSG  AWAREMHREQ  ITLPSGRFVS  SSYTGTSSNR240
ANPFLILSLK  DTCETSGSCI  GSHLIYSGNH  YEALEKDSYG  KVRFVTGIHP  RSFSWQLAPE300
ECFHTPEAVL  SFSAEGFRGL  SGQLHSFIRE  HIVRGVWKRR  PRPVLLNSWE  ACYFKIDEKK360
LLQLAKAGKE  AGIELFVMDD  GWFLGRNDDT  SSLGDWEADP  KKLPGGIASL  SKKINDLGMD420
FGIWVEPEMI  SENSRLYKEH  PDWAMKIPGH  PHSEGRNQCI  LDLCNPEVRQ  YVVEQMTKVF480
SSGDIRYVKW  DMNRIFSDIY  APSLPAEQQG  ETAHRYVLGL  YQIMEELTAR  FPEILFEGCS540
SGGNRFDLGI  LCYFPQIWAS  DNTDALCRTE  IQNNYSYGYP  LSVVTAHVSS  CPNHQTLRIT600
PLETRFQVAL  FGVLGYECNL  RDLSKKELQE  ISEQIALYKK  WREVLQFGTF  YRGKENADSD660
GETLSWTCVS  PDGRRAAGLF  FQRLATPNRP  HACYRPAGLL  SDVKYHFYSR  SIKYNLKDFG720
DLVNTVSPVH  IKQGSALQEI  LSRFVNMEGE  KEELTAYGDT  LMCAGVALKP  AFAGTGYNSD780
TRLFPDFSSR  IYFMEAVE798

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap397911915919923927931935939943847851855859863867871875812715GH36
Family Start End Evalue family coverage
GH36 12 715 1.8e-262 0.9811046511627907

CDD Domains      download full data without filtering help

Created with Snap3979119159199239279319359399438478518558598638678718758303648Melibiase12705GalA341640GH3629298Glyco_hydro_36N347423GH27
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam02065 Melibiase 0.0 303 648 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
COG3345 GalA 2.01e-172 12 705 4 646
Alpha-galactosidase [Carbohydrate transport and metabolism].
cd14791 GH36 4.33e-144 341 640 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 6.17e-93 29 298 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
cd14792 GH27 7.03e-13 347 423 6 84
glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.

CAZyme Hits      help

Created with Snap39791191591992392793193593994384785185585986386787187581798QNM04035.1|GH364795AEN96404.1|GH3612795CBL09633.1|GH3612795CBL11721.1|GH3612795VCV21698.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QNM04035.1 0.0 1 798 1 800
AEN96404.1 0.0 4 795 1 797
CBL09633.1 0.0 12 795 9 794
CBL11721.1 0.0 12 795 9 794
VCV21698.1 0.0 12 795 9 794

PDB Hits      download full data without filtering help

Created with Snap3979119159199239279319359399438478518558598638678718758127054FNR_A127054FNT_A127054FNP_A127054FNU_A126994FNQ_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNR_A 4.20e-186 12 705 12 690
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNT_A 4.71e-185 12 705 12 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 6.65e-185 12 705 12 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 1.33e-184 12 705 12 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNQ_A 3.74e-184 12 699 12 684
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap397911915919923927931935939943847851855859863867871875812705sp|Q9ALJ4|AGAA_GEOSE7705sp|G1UB44|MELA_LACAC12681sp|P43467|AGAL1_PEDPE1705sp|G4T4R7|AGASK_RUMGN84652sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 2.30e-185 12 705 12 690
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 3.12e-174 7 705 10 693
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 3.17e-171 12 681 13 668
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 5.84e-169 1 705 1 682
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
P27756 2.01e-141 84 652 74 632
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000060 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002247_00108.