logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000002445_00319

You are here: Home > Sequence: MGYG000002445_00319

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Clostridium_Q sp003024715
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Clostridium_Q; Clostridium_Q sp003024715
CAZyme ID MGYG000002445_00319
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
749 MGYG000002445_1|CGC2 85588.84 5.1255
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002445 3277016 Isolate South Korea Asia
Gene Location Start: 336514;  End: 338763  Strand: -

Full Sequence      Download help

MSIVYHESSK  IFHLYNQTIS  YIMMVLPNGH  MGQLYYGKKI  RDKEDFSYLL  ELAPRDMASY60
LYENDRTFSL  GHIKLEYGTY  GSGDYRHPAV  EILQNDGSTY  SDFQFTGYQV  TSGKPKLPGL120
PATYTEQDGE  AETLIITLKD  THTNLELHLL  YTIFVEGGVI  ARSASISNQG  DISVQVQTAM180
SLCLDLPDHD  YEWMQFSGAW  ARERALHTRR  LEYGIQAIDS  TRGHSSHEQN  PFIILKRPSA240
DEFQGEAIGC  SLIYSGNFLA  QAEVESHGTT  RLMIGINPFG  FSWELNPGET  FQTPEAVLVY300
SSQGLNDMSQ  TFHRLYRRRL  ARGYWRDRER  PILINNWEAT  YFNFTEEKLL  QLASRAQKCG360
IELFVLDDGW  FGARSSSKAG  LGDWEANRDR  LPNGLSGLAQ  KIEALGMKFG  LWIEPEMVNA420
DSDLFRTHPD  WILQVPGRTP  CHGRYQYVLD  FSRQEILDYI  YEKIASILEG  ASISYIKWDM480
NRSLSDVWSR  GVSARQQGEV  FHRYILGVYQ  MYERLTTRFP  DILFESCASG  GARFDAGMLY540
YAPQGWLSDN  TDAIERLRIQ  YGTSYGYPIS  SMGSHVSASP  NHQLHRQTPL  WTRANTAFFG600
TFGYELDLAQ  LGEDELSELK  IQTAFMKQHR  SLIQYGTFYR  LSSPFENNIT  AWMVVSEDRT660
EALVGWYRTL  NVANGPFTRL  YLQGLEESDL  YNVTEYTEGH  ESAVSTHYGD  ELMNLGLITS720
DASSGQYMDG  RRESCDFDSR  LFYVQKQAE749

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap377411214918722426229933737441144948652456159963667471111717GH36
Family Start End Evalue family coverage
GH36 11 717 1.2e-287 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap377411214918722426229933737441144948652456159963667471112717GalA290636Melibiase329628GH3629286Glyco_hydro_36N649743Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 12 717 4 665
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 290 636 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 7.48e-141 329 628 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 8.64e-124 29 286 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 1.70e-23 649 743 1 77
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap37741121491872242622993373744114494865245615996366747111744BDA09616.1|GH363744QRT48597.1|GH361744QIB59452.1|GH363744CBL25056.1|GH361744CBL06499.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
BDA09616.1 0.0 1 744 1 738
QRT48597.1 0.0 3 744 4 738
QIB59452.1 0.0 1 744 1 738
CBL25056.1 0.0 3 744 4 738
CBL06499.1 0.0 1 744 1 738

PDB Hits      download full data without filtering help

Created with Snap377411214918722426229933737441144948652456159963667471117244FNR_A17174FNQ_A17244FNU_A17244FNT_A17244FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNR_A 2.52e-266 1 724 1 715
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNQ_A 5.80e-265 1 717 1 708
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 2.34e-264 1 724 1 715
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 3.32e-264 1 724 1 715
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 4.70e-264 1 724 1 715
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap37741121491872242622993373744114494865245615996366747111724sp|Q9ALJ4|AGAA_GEOSE3717sp|G1UB44|MELA_LACAC7717sp|P43467|AGAL1_PEDPE1712sp|G4T4R7|AGASK_RUMGN71725sp|Q5AU92|AGALC_EMENI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 1.38e-265 1 724 1 715
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 3.56e-217 3 717 6 712
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 4.18e-216 7 717 8 711
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 2.59e-204 1 712 1 703
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q5AU92 3.27e-180 71 725 93 741
Alpha-galactosidase C OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=aglC PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000078 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002445_00319.