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CAZyme Information: MGYG000002492_00441

You are here: Home > Sequence: MGYG000002492_00441

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Agathobacter rectalis
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Agathobacter; Agathobacter rectalis
CAZyme ID MGYG000002492_00441
CAZy Family GH36
CAZyme Description Bifunctional alpha-galactosidase/sucrose kinase AgaSK
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
946 MGYG000002492_1|CGC6 106394.67 4.7313
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002492 3449685 Isolate not provided not provided
Gene Location Start: 447855;  End: 450695  Strand: +

Full Sequence      Download help

MAIIFNPNKK  IFTLQTAHTT  YQMQVDRLGY  LLHLYYGAKS  TCDMDYVLTY  ADRGFSGNPY60
AAGMNRTYSL  DTLPQEYPTL  GTGDFRNIAL  DIKNEQGTES  VELLYKSYEI  RDGKYALKGL120
PAVWASDDEA  QTLEIVLGDD  IAGVEVHLLY  GVLEACDVIT  RSVLIKNTGS  GNITIEKAHA180
ACLDMVYGDY  DVIRFYGKHA  MERNLERTHL  GHGTLSFGSR  RGTSSHQYNP  AVILAQRDTT240
ENAGDCYGML  FVYSGNFSCE  AEKDQINQTR  LLMGLSDELF  SYPLAAGETF  TVPEVIMSYS300
ADGFSQLSHQ  YHTCISEHVC  RSRFAHEVRP  VLINSWEAAY  FDFTGDTIVD  LAKEAASLGI360
DMVVMDDGWF  GKRDDDNSSL  GDWFVNEKKL  GGTLSELIDR  VHAQGVKFGI  WIEPEMVNED420
SNLYREHPDW  AIQIPGKLPV  RSRNQLILDF  SRKEVRDNIF  NQICAVFDQG  KIDYVKWDMN480
RSMADVYAGN  LAYDYVLGVY  DFMERLVTRY  PDILLEGCSG  GGGRFDAGML  YYSPQIWCSD540
NTDAINRTRI  QYGTSFFYPV  SSMGAHVSAV  PNHQTGRVTS  LKTRGITAMA  GTFGYELNPA600
LLSDEEKEEI  REQIKTFKKY  EMLINEGTYW  RLTSPFEDEV  AAWMSVSRTK  DRALVSVVRL660
YAEANAAACY  VKLKGLESDA  VYIEENTGRQ  YTGAALMNAG  IPLPFAVKEY  EAYQFSFIRL720
DEAKKLYDEI  KKVCGNLKLN  EADTADSASD  NRIVISIYGG  SGSGKTTIAA  ALQQYFLNDN780
TACYVLTGDN  YPHRIPMRND  EERLNVYNES  GEDGLRGYLG  TPKEIDFDRI  NKELSEFKAG840
KDIIEIKHMG  REDGDISYDE  TDFTGIKVLI  LEWTHGGSEY  LKGVDIPVFL  ESSPEETKAR900
RIKRGRDENA  ASPFICRVVE  LEQEKLDLQG  KNARIVVGKD  GKVYEQ946

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap479414118923628333137842547352056761466270975680485189811702GH36
Family Start End Evalue family coverage
GH36 11 702 3.9e-267 0.997093023255814

CDD Domains      download full data without filtering help

Created with Snap4794141189236283331378425473520567614662709756804851898289627Melibiase12701GalA329619GH3629285Glyco_hydro_36N640717Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam02065 Melibiase 0.0 289 627 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
COG3345 GalA 0.0 12 701 4 665
Alpha-galactosidase [Carbohydrate transport and metabolism].
cd14791 GH36 2.12e-141 329 619 2 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 3.33e-110 29 285 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 8.65e-24 640 717 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap47941411892362833313784254735205676146627097568048518981946ACR74280.1|GH361946CBK89379.1|GH361946CBK94329.1|GH361946AWY97922.1|GH361946ASM68469.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
ACR74280.1 0.0 1 946 7 952
CBK89379.1 0.0 1 946 1 946
CBK94329.1 0.0 1 946 1 946
AWY97922.1 0.0 1 946 1 935
ASM68469.1 0.0 1 946 1 935

PDB Hits      download full data without filtering help

Created with Snap479414118923628333137842547352056761466270975680485189817202YFN_A17054FNQ_A17104FNR_A37172XN0_A37172XN2_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2YFN_A 0.0 1 720 1 720
galactosidasedomain of alpha-galactosidase-sucrose kinase, AgaSK [[Ruminococcus] gnavus E1],2YFO_A GALACTOSIDASE DOMAIN OF ALPHA-GALACTOSIDASE-SUCROSE KINASE, AGASK, in complex with galactose [[Ruminococcus] gnavus E1]
4FNQ_A 5.23e-221 1 705 1 712
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 1.05e-220 1 710 1 717
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
2XN0_A 4.61e-220 3 717 6 728
Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN0_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN1_A Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_C Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_D Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM]
2XN2_A 9.22e-220 3 717 6 728
Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM with galactose [Lactobacillus acidophilus NCFM]

Swiss-Prot Hits      download full data without filtering help

Created with Snap47941411892362833313784254735205676146627097568048518981946sp|G4T4R7|AGASK_RUMGN1710sp|Q9ALJ4|AGAA_GEOSE3717sp|G1UB44|MELA_LACAC10722sp|P43467|AGAL1_PEDPE52719sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
G4T4R7 0.0 1 946 1 935
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q9ALJ4 5.72e-220 1 710 1 717
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 2.53e-219 3 717 6 728
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 3.03e-206 10 722 11 732
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
P27756 1.64e-173 52 719 50 719
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000071 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002492_00441.