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CAZyme Information: MGYG000002984_00178

You are here: Home > Sequence: MGYG000002984_00178

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA737 sp900554525
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UBA737; UBA737 sp900554525
CAZyme ID MGYG000002984_00178
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
724 81526 5.0306
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002984 1653947 MAG United States North America
Gene Location Start: 1369;  End: 3543  Strand: +

Full Sequence      Download help

MSVTYIPEKK  SFYLDGKNIS  YVFFINPYGY  AEHLYFGKKI  PHDDLTYSLI  SKDARAFNPT60
PPGKDGGYSY  QQSPTELSFF  GIGDYREPCV  ITENPSGDRL  CELLYDGYEI  LKTKPGIKGL120
PSMDGGETLI  INLKDSVTGF  AADLYYTVYE  DCDVISRRIV  YKNLGGKSII  LRRAYSFSLS180
LPGHGYDFVS  LYGSWAKERH  IEKIPLHHGV  VSIDSKRAAS  SAVLNPFIAL  QSRGSTEETG240
EVFGVSLVYS  SSFVLKAQCT  LDGETMVTGG  IQDFNFSWSL  KPGESFETPE  AVIAFSAEGM300
GGMSRAFHYA  FRNHLINKRY  VKAARPLLIN  NWEGTYYDFD  AAKLNAMVDA  VADTGIDTFV360
LDDGWFGVRN  DDTSSLGDWF  VNTEKLPGGL  NEVIDHVHSK  GMKFGLWFEP  EMISENSELY420
RAHPEYAIKA  PDRPGCYWRH  QFMLDLTNSE  VRDYIVNSVN  SILNTHAIDY  VKWDYNRNVT480
EFYSGVLPAE  AQGEFCHRYV  LGVYDLCERI  VEANPHIFFE  GCSGGGARFD  PAMLKYFPQI540
WTSDDTDAEE  RTLIQYGTSL  VYPLSAMSCH  VSKVPNEQTE  RSTPLETRAH  IASLGATGYE600
FDPTELSAEE  LGKIKDYVKE  YREQADLILN  GDLYRIENPF  ESNFFGMMIV  SEDKASAVLT660
AYRRLGSVNE  EIKRIRLSGL  EPSYTYFIPE  LDLKLSGAVL  MNVGIVPKFG  SGDFKSLRWH720
FIKK724

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367210814418121725328932536239843447050654357961565168712705GH36
Family Start End Evalue family coverage
GH36 12 705 1.5e-252 0.9941860465116279

CDD Domains      download full data without filtering help

Created with Snap367210814418121725328932536239843447050654357961565168712716GalA285631Melibiase324623GH3629281Glyco_hydro_36N648721Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 12 716 4 679
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 9.50e-180 285 631 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 5.81e-137 324 623 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 1.76e-89 29 281 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 2.95e-20 648 721 5 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36721081441812172532893253623984344705065435796156516871719AGF54592.1|GH361719AQR93549.1|GH361717AIQ37151.1|GH361717AWV35115.1|GH361722QQZ61862.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
AGF54592.1 1.93e-224 1 719 1 724
AQR93549.1 6.24e-223 1 719 1 724
AIQ37151.1 2.34e-222 1 717 1 720
AWV35115.1 3.55e-222 1 717 1 722
QQZ61862.1 3.79e-222 1 722 1 726

PDB Hits      download full data without filtering help

Created with Snap367210814418121725328932536239843447050654357961565168717194FNQ_A17194FNR_A17194FNP_A17194FNU_A17194FNT_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 6.13e-211 1 719 1 722
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 2.89e-206 1 719 1 722
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNP_A 2.31e-205 1 719 1 722
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 9.27e-205 1 719 1 722
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 1.31e-204 1 719 1 722
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36721081441812172532893253623984344705065435796156516871719sp|Q9ALJ4|AGAA_GEOSE8721sp|G1UB44|MELA_LACAC3721sp|P43467|AGAL1_PEDPE1709sp|G4T4R7|AGASK_RUMGN32724sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 1.58e-205 1 719 1 722
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 9.90e-191 8 721 11 728
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.66e-186 3 721 4 727
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 8.15e-183 1 709 1 706
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
P27756 2.03e-169 32 724 31 720
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000081 0.000002 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002984_00178.