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CAZyme Information: MGYG000003504_00449

You are here: Home > Sequence: MGYG000003504_00449

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species CAG-1435 sp003537755
Lineage Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-314; CAG-1435; CAG-1435 sp003537755
CAZyme ID MGYG000003504_00449
CAZy Family GH36
CAZyme Description Bifunctional alpha-galactosidase/sucrose kinase AgaSK
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
726 MGYG000003504_28|CGC1 83413.74 5.3231
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003504 2246614 MAG Fiji Oceania
Gene Location Start: 6512;  End: 8692  Strand: -

Full Sequence      Download help

MITFDKASNV  VKLTNGKIDY  AVYINTEGYL  ETVYFGKSIR  NFDPTTMRTA  PKWHAETHVY60
DPAIGSERWF  ADGFKQNVAP  LEISPHARRD  KRGAPVICAR  ENGSFATDFL  YVSHRIFDGT120
EPLDGLPSVH  GDNCQTVEFL  LKERTRELYV  KHHITIFDDC  DIVVKNYTIV  NKTGLDVTLS180
RAMSMQLDLP  RNNYNLTHFS  GRWAAERNAV  TNKLVDGVQE  VSSNLGATSA  EESSFLYLAE240
DGATYTHGEV  LGFNLVYSGN  FKFRICSDMM  KGTHITYGIN  DEDFAWVLAD  GESFVTPQAV300
VCYSADGIDG  MSRSMHDFVR  NHIVTYRHDR  EYKPVLFNSW  EGCYFTFTTD  SILSYIDDSE360
KIGAELFVLD  DGWFGRRNDD  LDGLGDWQIN  TDKIDLGKVI  DHCHSKGIKF  GIWFEPEMIN420
FTSDLFKAHP  DYALREDKED  VFLGRHQMHL  DMTRDDVVDN  IYNQMIAILD  NYDIDYVKWD480
YNRRVYEHYS  RHLGADRQGE  VYHRLTLGYY  KLLGRIAARY  PDMMIEGCAG  GGARFDLGTL540
CYCPQIWTSD  ESNPARRCTI  NYNTSFGYPL  CTMGTHVNDC  KLFDYRAKGQ  FALFGTYGYE600
MNPNKLTAEE  IGMLNETAEL  YKRYHKDVVE  NGDLYHIADP  SDGEYYIMQC  VSKDKSTSLV660
LSMNLKCQKD  CFRFVRLRGL  QADKLYTNSH  DGKAYYGDYY  MNVGLNLSLD  WHQEFECQLF720
VLKEVK726

Enzyme Prediction      help

No EC number prediction in MGYG000003504_00449.

CAZyme Signature Domains help

Created with Snap367210814518121725429032636339943547150854458061765368911706GH36
Family Start End Evalue family coverage
GH36 11 706 6.1e-207 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap36721081451812172542903263633994354715085445806176536899709GalA293632Melibiase332623GH3628289Glyco_hydro_36N649722Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 1.61e-131 9 709 2 669
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 5.25e-129 293 632 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 2.38e-108 332 623 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 4.81e-69 28 289 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 3.14e-15 649 722 5 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36721081451812172542903263633994354715085445806176536892712ALC89422.1|GH362715AGY82470.1|GH362726ANX00450.1|GH362726AGI38523.1|GH362726AGC67465.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
ALC89422.1 5.70e-159 2 712 3 717
AGY82470.1 8.42e-159 2 715 3 719
ANX00450.1 4.71e-158 2 726 3 732
AGI38523.1 6.64e-158 2 726 3 732
AGC67465.1 6.64e-158 2 726 3 732

PDB Hits      download full data without filtering help

Created with Snap367210814518121725429032636339943547150854458061765368927252YFN_A17252XN0_A17252XN2_A27074FNQ_A27074FNR_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2YFN_A 5.13e-145 2 725 3 720
galactosidasedomain of alpha-galactosidase-sucrose kinase, AgaSK [[Ruminococcus] gnavus E1],2YFO_A GALACTOSIDASE DOMAIN OF ALPHA-GALACTOSIDASE-SUCROSE KINASE, AGASK, in complex with galactose [[Ruminococcus] gnavus E1]
2XN0_A 6.26e-143 1 725 5 731
Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN0_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN1_A Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_C Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_D Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM]
2XN2_A 1.24e-142 1 725 5 731
Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM with galactose [Lactobacillus acidophilus NCFM]
4FNQ_A 5.44e-140 2 707 3 710
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 4.66e-138 2 707 3 710
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36721081451812172542903263633994354715085445806176536892726sp|G4T4R7|AGASK_RUMGN1725sp|G1UB44|MELA_LACAC2707sp|Q9ALJ4|AGAA_GEOSE1704sp|P43467|AGAL1_PEDPE86724sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
G4T4R7 1.70e-142 2 726 3 721
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
G1UB44 3.43e-142 1 725 5 731
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
Q9ALJ4 2.55e-137 2 707 3 710
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
P43467 9.52e-123 1 704 3 710
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
P27756 6.25e-115 86 724 76 720
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000056 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003504_00449.