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CAZyme Information: MGYG000003987_00388

You are here: Home > Sequence: MGYG000003987_00388

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA1691 sp900544375
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UBA1691; UBA1691 sp900544375
CAZyme ID MGYG000003987_00388
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
810 MGYG000003987_9|CGC1 92426.62 6.333
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003987 2710592 MAG United Kingdom Europe
Gene Location Start: 509;  End: 2941  Strand: +

Full Sequence      Download help

MIQITSQKTF  HLSTEKTSYL  FRALPCGKLE  QLYYGRKIPA  CEEYTFLYDK  HAAGYSNTTV60
YDKKDHLSLD  HIRLDYSEFG  KGDYRLPAMQ  VQAENGNFNC  DFKFLDAKVT  DTKPELAGLP120
SSYGASQTLT  VIMEDKALCA  QLHLFYTVFE  NCNVITRSAR  LINNGEKTIK  IHSLMSMQID180
LPAGDYTMIS  FDGAWIRERY  QHERKLTAGE  CSIGSICGTS  SNRHNPFFAI  RKGDCNEQAG240
ECWGINLVYS  GNHIGRVEVA  PHGMVRVQNG  INPFEFEWAL  APGQSFDAPE  SVLTYSHEGL300
NGMSRNMHAF  VKEHIVRGEW  KHKERPIVVN  NWEATYFQFT  EKKILAIAKE  GARLGAELFV360
LDDGWFGKRN  SDQSSLGDWW  VNKKKLPSGI  DGLARKINEM  GLKFGLWVEP  EMVNPDSDLY420
RAHPDWAMTT  NDYEPTEGRN  QLVLDLTNPD  VQQYLIDTIT  DVIKLGNIEY  IKWDMNRQFS480
DVFGRTLGTR  QGEYFHRYYL  GLYNILQALC  DRFPHVLFES  CSSGGNRFDL  GMFCYMPQCW540
TSDNTDPLDR  IRIQTGTSYG  YPQSVMTMHV  SASPSFASLR  VSSIEERFNV  ASFGLMGYEM600
DVTNLSSFDR  AAVKKQIAFY  KEHRRLLQFG  EFYRIGNPFK  ENTCAWQVVS  PDRAESMLGC660
FIDRLTPNSG  PDRLAFTGLD  PEKVYRFTAR  QQLLNLRTFG  EIINTPLPRK  FDMEDGKVYN720
LLTDHIRLHS  EKEEYTLPGA  ALLYAGLVPC  QMFVLSGYNG  KTRVLTDTDS  RVYYLHETAR780
EEEIIGGAEE  TTSIVLHKAS  FGTQREEKNV  810

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap408112116220224328332436440544548652656760764868872976910691GH36
Family Start End Evalue family coverage
GH36 10 691 1.7e-268 0.9752906976744186

CDD Domains      download full data without filtering help

Created with Snap4081121162202243283324364405445486526567607648688729769285630Melibiase10685GalA324622GH3627281Glyco_hydro_36N330406GH27
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam02065 Melibiase 0.0 285 630 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
COG3345 GalA 0.0 10 685 4 646
Alpha-galactosidase [Carbohydrate transport and metabolism].
cd14791 GH36 1.01e-141 324 622 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 2.75e-100 27 281 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
cd14792 GH27 1.40e-11 330 406 6 84
glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.

CAZyme Hits      help

Created with Snap40811211622022432833243644054454865265676076486887297696775QEN07610.1|GH361775QOS41139.1|GH368777CBK74351.1|GH368774QFJ55825.1|GH361783QUH31721.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QEN07610.1 2.26e-250 6 775 19 793
QOS41139.1 1.92e-249 1 775 1 777
CBK74351.1 3.73e-249 8 777 7 777
QFJ55825.1 4.25e-248 8 774 7 774
QUH31721.1 3.33e-245 1 783 1 790

PDB Hits      download full data without filtering help

Created with Snap408112116220224328332436440544548652656760764868872976986854FNQ_A86854FNR_A86854FNT_A86854FNP_A86854FNU_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 3.71e-216 8 685 10 690
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 5.95e-215 8 685 10 690
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNT_A 6.74e-214 8 685 10 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 9.54e-214 8 685 10 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 1.91e-213 8 685 10 690
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap40811211622022432833243644054454865265676076486887297698685sp|Q9ALJ4|AGAA_GEOSE6693sp|P43467|AGAL1_PEDPE8686sp|G1UB44|MELA_LACAC6685sp|G4T4R7|AGASK_RUMGN4638sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 3.26e-214 8 685 10 690
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
P43467 1.52e-184 6 693 9 700
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G1UB44 4.06e-175 8 686 13 694
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
G4T4R7 1.31e-167 6 685 8 682
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
P27756 6.75e-157 4 638 4 636
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000033 0.000013 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003987_00388.