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CAZyme Information: MGYG000002178_00112
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; CAG-617; | |||||||||||
| CAZyme ID | MGYG000002178_00112 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 32444; End: 34639 Strand: + | |||||||||||
Full Sequence Download help
| MYTILKRFFL LLSVMFLSTP LIATAQRDTI IAGLLERIGG RGAAERFVWE IRPEMSPTGC | 60 |
| DVFEIASRDG KPYVAGSSAL AVATGIGWYL NHTACVNLTW NRPHADLARL TLPLPKGKER | 120 |
| REARVAWRYY LNYCTFSYST AFWDWERWQQ EIDWMALHGV NMPLAAVGTD VVWRNVLHEL | 180 |
| GYTQAEIDRF IAGPAHQAWW LMNNLEGWGG PNPEQWYAAR ERLARKIVER MRAFGMEPVL | 240 |
| PGYAGMVPAD AGEKLDWDVK DAGNWCGFRR PGFLLPTDPH FASMAALYYK YLTRLVGVSS | 300 |
| LYSIDPFHEG GNTAGVDLPA AYRAIEQAML RVNPSARWVV QSWNENPRPE CLRTIQSGRL | 360 |
| IVLDLFSDGQ PKWHDGYGGH DWMFCMLHNF GGRVGVHGRY RAVIDGYYDA LSRYPSTLKG | 420 |
| IGATPEGIET NPMLYDMLFE LPWRSEDEMG GWLEAYVKAR YGSSRPELLK AWDALTGSVY | 480 |
| DCRTRQQGAT ESVMCARPSL DVRSVSTWST AQPYYQADSL VKAAALLLAC GHSLRSSDNF | 540 |
| AYDLTDVMRQ VLADSAYALS RQIAPAARQK DTAALRRLRD SFLQLILDLD RLLATRPEFM | 600 |
| LGRWTSAARH LADEVCPGDA RYADEMERNA RTLITVWGTE TAANAGGLHD YANREWAGLL | 660 |
| RDFHYVRWQR FFDALIGGKP LPAPGEWYEM EEGWTRNFSL CYADVPQGDS YDVAHALFCK | 720 |
| YFGNPSAFLG K | 731 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 70 | 718 | 1.9e-225 | 0.9924585218702866 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 2.00e-172 | 128 | 445 | 1 | 333 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 8.45e-84 | 452 | 715 | 1 | 258 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 1.41e-15 | 31 | 113 | 3 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QFQ12583.1 | 1.98e-260 | 10 | 723 | 4 | 719 |
| QRO24616.1 | 1.45e-246 | 6 | 714 | 2 | 708 |
| QQT77518.1 | 2.94e-238 | 10 | 696 | 5 | 702 |
| QRP57238.1 | 2.94e-238 | 10 | 696 | 5 | 702 |
| ASM65926.1 | 2.94e-238 | 10 | 696 | 5 | 702 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2VC9_A | 1.53e-148 | 23 | 699 | 164 | 851 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 1.89e-148 | 23 | 699 | 172 | 859 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 2.16e-147 | 23 | 699 | 187 | 874 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
| 4XWH_A | 9.76e-120 | 25 | 722 | 3 | 712 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P54802 | 9.79e-119 | 25 | 722 | 26 | 735 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| Q9FNA3 | 1.90e-111 | 17 | 722 | 35 | 805 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000303 | 0.999058 | 0.000166 | 0.000178 | 0.000142 | 0.000136 |