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CAZyme Information: MGYG000003987_00564
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | UBA1691 sp900544375 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UBA1691; UBA1691 sp900544375 | |||||||||||
| CAZyme ID | MGYG000003987_00564 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 10389; End: 12593 Strand: - | |||||||||||
Full Sequence Download help
| MQYQSVYDLI RRALPGKESC FLLREMKVEE AATGQNCYCV SSEGEKIILS GDCVISLCMA | 60 |
| FYAYLREECG VNLSWCGNRE IAVPEELPVP AVERRYAVPQ QHRVYMNYCT FGYSALVWDW | 120 |
| ARWEQEIDFM AMNGVNMPLS IIGTQGVGFE TLLEYGFTER EALAYLSGPA YWPWQLMTNL | 180 |
| EGAMPPPDRR YVEQSISLGR KILERERSLG MTPIQQGYSG HVPRLFRQKF PQARIRETGG | 240 |
| WCGFPPTAQL DPLDPLFARF GLSLLKKQEE LFGCERYLAC DPFHENSPSV KGKAYLSKVG | 300 |
| RAIDELYRSF RPDSIWVMQS WSLRKAIVKA VPKERLLILD LNSARAKGTK GFWGYPYVAG | 360 |
| ELHNFGGKNS LHGDLEAAAS FSYRKQQKKH PNLTGAGLFM EGINQNPLFY DLQFTMLTQA | 420 |
| EGVNLQQWLA DYAVRRYGSD EACLREALRL LRMSCYAAKT SDSERGSILC ARPHWWIDRA | 480 |
| APNDMIEIRY SNRMLLRALE KLLEAKRAGK DGYAFDLCDI ARQALSNHAL SLYNQAMDGF | 540 |
| FQHNRAMFEH ASASFLELLQ DMDRLLATRP ELRLSRWAER AQKLGEDETM ASYYRENALA | 600 |
| LITLWGPAEE PIIFDYAWRE WSGLMQQFYG MRWRMFFAFT LEHFDTLPRK KDRGIRQIYG | 660 |
| RDPFDATPFL HEIGQRERAF IREYRPAPEQ AGETVAVVRD LLQKYAAAIS DDTTLPYMKE | 720 |
| QANKKPHRFA VLFS | 734 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 44 | 646 | 4.4e-181 | 0.9291101055806938 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 2.93e-135 | 103 | 412 | 1 | 325 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 1.72e-73 | 428 | 699 | 1 | 258 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 3.04e-17 | 4 | 88 | 1 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUT48266.1 | 3.22e-207 | 4 | 705 | 24 | 724 |
| QDO68352.1 | 5.02e-207 | 4 | 705 | 26 | 726 |
| ALJ60114.1 | 1.61e-205 | 4 | 705 | 26 | 726 |
| QUT88879.1 | 1.61e-205 | 4 | 705 | 26 | 726 |
| QQT79630.1 | 2.93e-205 | 4 | 707 | 24 | 727 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4XWH_A | 4.58e-101 | 5 | 705 | 8 | 711 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
| 2VC9_A | 3.89e-96 | 27 | 633 | 193 | 817 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 4.53e-96 | 27 | 633 | 201 | 825 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 4.33e-95 | 27 | 633 | 216 | 840 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P54802 | 3.10e-100 | 5 | 705 | 31 | 734 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| Q9FNA3 | 5.37e-96 | 1 | 705 | 44 | 804 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000067 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |