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CAZyme Information: MGYG000001406.1_00046
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Kurthia massiliensis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Bacillales_A; Planococcaceae; Kurthia; Kurthia massiliensis | |||||||||||
| CAZyme ID | MGYG000001406.1_00046 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Dimodular nonribosomal peptide synthase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 34831; End: 41640 Strand: - | |||||||||||
Full Sequence Download help
| MQLLTDAQQT MWYAHQLNPE HTNFITAEYV TFKGDIQLGV LRLAFEKTLT QVESLQQQFV | 60 |
| ERDGKVYQQT VPRDIHIPVI HTTDAIAWMK QRLTAPLHIE NGILFEAAFV CNDNTHDVHF | 120 |
| FFKVHHIAID AFGYQLIYRA AAQQYEALLE ERELLSVFGD YERVVAEQLA YTKHEQYAQD | 180 |
| KQFWQQYLRL DDELATFSQR PVTLDGHVHQ AVTDFKAEDV QRWQQRSFAE KLMPQHYLMA | 240 |
| AFACLTYKVT HKTSVVINVP FMNRFGHAAA TVPCLQMNTV PLQIELSPTM TLIDVAKLIQ | 300 |
| REEARIKQHS LYRFEHIRRD AGFAYDERIC TGQFNFMPFY EVLTFGCAQA ETHKLSIGVI | 360 |
| DDLSFNVFAT ANGMRCELLG NSAIYDEQTL SMWLSYYTTI LHEQQMPLYR YLQTDVMALA | 420 |
| PFVSQPDILT QIHRQVRKYP EKIAIQSEQY AVTYAQLDEE SDRIAYWLCQ QGVQPGDDVA | 480 |
| LYLPRTPKLI ACMIAVLKIR ATYIPLDPVY PLERIQYIVQ DAQAKVLLCE GDVALNVPQL | 540 |
| DVTSSPWQHS PRYEDVALVA SDIAYKIYTS GSTGNPKGVV VGRAQLSNFL IGMQDVLPVS | 600 |
| DATSLLAVTT NAFDISMLEC FLPLTVGGKV VLSTASQVHD PLALKMLIDQ YHINMIQATP | 660 |
| SLWKMLVDYM PASLHNVVAL VGGEALPERL AQKMLAHTQL VFNMYGPTET TIWSTVAPIK | 720 |
| EAAAITLGQP IAQTAIYILD DDLQPVLPGT EGHLYIAGAG VAQGYDNRPA LTASRFIANP | 780 |
| FTNDGTRMYQ TGDVVKMVDG QLHYIGRTDF QVKIRGFRIE LQEIERALTA IQGVQEALVL | 840 |
| AQKINDTDQL VAYVMSAHAI DVDKYTMLLE KTLPAYMIPT YWVAMDKWPM TNNGKIDRKA | 900 |
| LPMPALSTAG AALSTKTEVQ LAKLYEEILN LSAVDADSHF FRLGGHSLLA TALMMRIRDI | 960 |
| WRCDITIATI FAAPTVRTLA KAIDDAQSTA IWPVLEQVPS SAYVPLSATQ KGMWFMQHTQ | 1020 |
| PSATYNIPLI IENVSLDEAR LVQALAILQQ QHPILRTVYE LVDGVPMQRY TDQQIPIIHS | 1080 |
| SRENIDDDAH TLFDLATELS VKVFVYDDTI QFLWHHIAID GYGLSVFLKD LAFAYEQLKP | 1140 |
| RTTPLSYASY VEWQRKLLET SYATKGLDYW GQQLKDVPTE ITLPVEASST EVAGDYEWYT | 1200 |
| LKPETFHTLQ RIAQAQGVSL YTVLQTAFSI VLHKMGAGDD ITIGSPTNGR PIAPLQQMIG | 1260 |
| LMMNTVVYRY QFTPGETIVE AITATHQMNE KAYAYDFVPF DRVVERVNPD RTSAKNPLFD | 1320 |
| VMMTMQNNPE LTLTLDGRTL PVRLMPTATS KVSLAVEVMN DAQTLKMLTS YDPSKFSKKI | 1380 |
| IVQLMARFEQ VIQQMQNGAQ RIEDVSLLLS GEYEALRTQS TPQPAQFTPM TIVERFEAIA | 1440 |
| MKHASRIAIV DGEKRYTYAA LNERANQLAR HLEAQGVERH DHVALVLSRQ YDMLVSLLAI | 1500 |
| LKVGATYVPI DPQYPEERVA YILQSAKPIL TIVETTPTAQ QIALDDIPYA QYMATNLDKC | 1560 |
| VVPEDPAYII YTSGSTGKPK GVVIPHSNVL RLLDATAHWY QFNENDCWTF FHSYAFDFSI | 1620 |
| WEIWGALLTG GKLVIVPYEV SRTPSEFHAL LISENVTVLN QTPSAFYQLL IADATASRRL | 1680 |
| QLRYIIFGGE ALSFERIRPW YDKYGETTTL VNMYGITETT VHVSYQRLNR DIVQQKQASL | 1740 |
| IGEAIPDLEI YVLDAALRPV PAGVIGEMYV AGDGLAHGYL GRPALTAERF IANPFKQDGS | 1800 |
| RMYRTGDLAK WTTDGNLAYI GRIDHQVKIR GFRIELDEIE SALLQLPYVH EAIAVTKQYS | 1860 |
| DDDVRMIAYV VADEWDVQQA TKHLATLLPN YMMPNAYVAL EEMPLTPNGK LDVKALPQPQ | 1920 |
| FATSEDHPTN PTEEVMLQLF RETLQNDALG IHDSFFEVGG HSLLAVQLMT KIKQTFDVTL | 1980 |
| SIGHLFEAPS VSKICANLTT FDEQHSLQTL LPLRPTASEQ PLFCVHPAGG LSWCYAGFMQ | 2040 |
| HLAPEQALYG LQAVGIAEEV TRPNTLTEMA KGYVDALRNV QPKGPYTLLG WSLGGNVVQE | 2100 |
| MACQLEAAHE CVTLIILDAY PVHHQLGDQT LEEEAVEALL ALGGLDVELI EGEMTLDNVI | 2160 |
| ALLKREGSAL ASLSVDTLQR LLKTYMNSIT LLRAHEPRRC EAEVMFYQST ILPEWFEKVD | 2220 |
| PMIWQPYVGT LHIEEVACRH KDMCQPVPIR TIGQHLAQFL QQKGKMIHV | 2269 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK12316 | PRK12316 | 0.0 | 418 | 1991 | 1995 | 3615 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 979 | 2049 | 25 | 1139 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 979 | 2022 | 25 | 1103 | peptide synthase; Provisional |
| cd05930 | A_NRPS | 0.0 | 1446 | 1916 | 3 | 444 | The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
| PRK12467 | PRK12467 | 0.0 | 1005 | 2146 | 2648 | 3818 | peptide synthase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 2.30e-247 | 440 | 2115 | 1023 | 2780 |
| ACX49739.1 | 1.60e-154 | 4 | 1642 | 12 | 1793 |
| BAY30132.1 | 9.70e-154 | 918 | 2117 | 2149 | 3413 |
| BAY90071.1 | 2.17e-152 | 873 | 2117 | 2081 | 3402 |
| BAZ75991.1 | 2.78e-151 | 918 | 2117 | 2147 | 3411 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6MFZ_A | 1.08e-216 | 434 | 2000 | 213 | 1799 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 6MFY_A | 2.48e-204 | 434 | 1919 | 213 | 1715 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
| 5U89_A | 1.07e-186 | 425 | 1358 | 23 | 1005 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
| 4ZXH_A | 1.06e-130 | 1006 | 2117 | 19 | 1162 | ChainA, ABBFA_003403 [Acinetobacter baumannii AB307-0294],4ZXI_A Chain A, Tyrocidine synthetase 3 [Acinetobacter baumannii AB307-0294] |
| 6N8E_A | 1.50e-130 | 1004 | 2055 | 30 | 1128 | Crystalstructure of holo-ObiF1, a five domain nonribosomal peptide synthetase from Burkholderia diffusa [Burkholderia diffusa] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P45745 | 0.0 | 4 | 2265 | 11 | 2378 | Dimodular nonribosomal peptide synthase OS=Bacillus subtilis (strain 168) OX=224308 GN=dhbF PE=1 SV=4 |
| P39846 | 3.35e-263 | 277 | 1998 | 300 | 2076 | Plipastatin synthase subunit B OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsB PE=1 SV=1 |
| O30409 | 2.18e-252 | 7 | 2120 | 4171 | 6344 | Tyrocidine synthase 3 OS=Brevibacillus parabrevis OX=54914 GN=tycC PE=1 SV=1 |
| P0C064 | 6.23e-246 | 4 | 2134 | 2099 | 4310 | Gramicidin S synthase 2 OS=Brevibacillus brevis OX=1393 GN=grsB PE=1 SV=2 |
| Q70LM6 | 3.25e-245 | 120 | 2015 | 2712 | 4692 | Linear gramicidin synthase subunit B OS=Brevibacillus parabrevis OX=54914 GN=lgrB PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000031 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |