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CAZyme Information: MGYG000000007_00832

You are here: Home > Sequence: MGYG000000007_00832

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Lactobacillus intestinalis
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus; Lactobacillus intestinalis
CAZyme ID MGYG000000007_00832
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
368 MGYG000000007_3|CGC3 40645.21 8.767
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000007 2016167 Isolate United Kingdom Europe
Gene Location Start: 222853;  End: 223959  Strand: -

Full Sequence      Download help

MRVIFTGGGT  GGHIYPIMAV  IERLKERGIS  TNDDILFVGT  QKGLESKIVP  AAGVNFKTIK60
IQGFNRKHPL  KNFETIELFF  KATKRAKEIL  NDFKPDIVVG  TGGYVSGAMV  YEAAKMHIPT120
MIHESNSVVG  LANKFLGHYV  DKICYTFDDA  AKQFPEKKKL  VKTGNPRSQQ  VLGLHENEID180
LQTKWGLNPQ  MPTVLVFGGS  RGALAINRIM  LKSVMELNKK  PYQIIWATGT  YYYDAVEKKL240
KDIDLGDNIK  VLPYIKNMPA  LLPEMTCVVS  RSGATSIAEF  TALGVPAILI  PSPNVTHNHQ300
MKNALDLEKA  GAALVIPEDD  LNPNNFVSSI  DHILLDEKYA  TEMSKASKEL  GVPDASDQVI360
KVMEEISR368

Enzyme Prediction      help

No EC number prediction in MGYG000000007_00832.

CAZyme Signature Domains help

Created with Snap1836557392110128147165184202220239257276294312331349193355GT28
Family Start End Evalue family coverage
GT28 193 355 2.5e-48 0.9936305732484076

CDD Domains      download full data without filtering help

Created with Snap18365573921101281471651842022202392572762943123313491368murG2362GT28_MurG1368MurG1362murG193359Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 4.82e-161 1 368 2 356
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.17e-141 2 362 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 1.34e-112 1 368 1 356
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 5.39e-106 1 362 1 347
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 6.78e-48 193 359 1 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap18365573921101281471651842022202392572762943123313491368ASN46710.1|GT281368AGK94003.1|GT281368AVW86623.1|GT281368ASX14771.1|GT281368AJP46232.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
ASN46710.1 1.86e-246 1 368 1 368
AGK94003.1 1.86e-246 1 368 1 368
AVW86623.1 1.86e-246 1 368 1 368
ASX14771.1 1.86e-246 1 368 1 368
AJP46232.1 1.86e-246 1 368 1 368

PDB Hits      download full data without filtering help

Created with Snap183655739211012814716518420222023925727629431233134923683S2U_A23667D1I_A23681F0K_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.32e-48 2 368 4 356
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 3.85e-47 2 366 11 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 6.12e-44 2 368 8 355
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18365573921101281471651842022202392572762943123313491368sp|Q5FKV2|MURG_LACAC1368sp|A8YUN9|MURG_LACH41368sp|Q04B72|MURG_LACDB1368sp|Q1GAT5|MURG_LACDA1364sp|Q042P9|MURG_LACGA
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q5FKV2 1.06e-246 1 368 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=murG PE=3 SV=1
A8YUN9 3.55e-245 1 368 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactobacillus helveticus (strain DPC 4571) OX=405566 GN=murG PE=3 SV=1
Q04B72 1.11e-221 1 368 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18) OX=321956 GN=murG PE=3 SV=1
Q1GAT5 1.11e-221 1 368 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) OX=390333 GN=murG PE=3 SV=1
Q042P9 1.23e-218 1 364 1 364
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63) OX=324831 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000072 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000007_00832.