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CAZyme Information: MGYG000001430_00397

You are here: Home > Sequence: MGYG000001430_00397

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Holdemania massiliensis
Lineage Bacteria; Firmicutes; Bacilli; Erysipelotrichales; Erysipelotrichaceae; Holdemania; Holdemania massiliensis
CAZyme ID MGYG000001430_00397
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
357 MGYG000001430_1|CGC4 38489.64 9.435
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001430 3757342 Isolate not provided Europe
Gene Location Start: 415476;  End: 416549  Strand: +

Full Sequence      Download help

MRVLIATGGT  GGHIYPALAL  ADAMKEKDPK  TEILFVGTAN  RMEATEIPKA  GYRFEAIKAK60
GLNGSALAKV  QAIVQLVHAY  FACRKIVRQF  RPDYAIGFGN  YISAPVILAA  HFAHVPTMLH120
EQNSYAGKAN  RFLAQYADKI  VGCYPENLQQ  FPASKTRILG  NPRASVAAQA  QRDPQVVRQL180
GLDPTKPLIV  VVMGSLGSES  VNAVMVKALK  SMAGKAYQVL  YVTGRAAYQQ  VQSQGLECAN240
IKVVEYIDGV  RVMVNADLAV  VRGGATTAAE  ITVLGLPAII  IPSPYVPNNH  QVLNAKALQE300
AGAALMIEEK  DLTDAEITAK  IEGVIFDPIR  LEGMRAAAKR  LGHPDANEQI  YNWIQQG357

Enzyme Prediction      help

No EC number prediction in MGYG000001430_00397.

CAZyme Signature Domains help

Created with Snap1735537189107124142160178196214232249267285303321339189346GT28
Family Start End Evalue family coverage
GT28 189 346 1.5e-42 0.9872611464968153

CDD Domains      download full data without filtering help

Created with Snap17355371891071241421601781962142322492672853033213391352murG2352GT28_MurG1354murG1352MurG3140Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.34e-122 1 352 2 349
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 8.27e-118 2 352 1 349
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
TIGR01133 murG 1.54e-95 1 354 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0707 MurG 1.44e-94 1 352 1 349
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
pfam03033 Glyco_transf_28 9.44e-36 3 140 1 137
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap17355371891071241421601781962142322492672853033213391356ANU70205.1|GT281356QJA03401.1|GT281356ASU17375.1|GT281356QQR25927.1|GT281356QSI25595.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
ANU70205.1 4.14e-117 1 356 1 354
QJA03401.1 4.14e-117 1 356 1 354
ASU17375.1 4.14e-117 1 356 1 354
QQR25927.1 4.14e-117 1 356 1 354
QSI25595.1 8.31e-117 1 356 1 354

PDB Hits      download full data without filtering help

Created with Snap173553718910712414216017819621423224926728530332133923503S2U_A23561F0K_A23567D1I_A23503OTG_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.70e-50 2 350 4 347
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
1F0K_A 3.72e-48 2 356 8 352
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 8.31e-37 2 356 11 364
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
3OTG_A 1.75e-09 2 350 22 399
CrystalStructure of CalG1, Calicheamicin Glycostyltransferase, TDP bound form [Micromonospora echinospora],3OTH_A Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form [Micromonospora echinospora],3OTH_B Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form [Micromonospora echinospora]

Swiss-Prot Hits      download full data without filtering help

Created with Snap17355371891071241421601781962142322492672853033213391355sp|O07109|MURG_ENTFA1351sp|Q812W5|MURG1_BACCR1355sp|Q88V81|MURG_LACPL1356sp|A7GRN6|MURG_BACCN1351sp|B7GGI2|MURG_ANOFW
Hit ID E-Value Query Start Query End Hit Start Hit End Description
O07109 3.53e-89 1 355 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Enterococcus faecalis (strain ATCC 700802 / V583) OX=226185 GN=murG PE=3 SV=2
Q812W5 8.25e-88 1 351 1 355
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1 OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) OX=226900 GN=murG1 PE=3 SV=1
Q88V81 1.13e-87 1 355 1 359
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) OX=220668 GN=murG PE=3 SV=1
A7GRN6 2.64e-86 1 356 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) OX=315749 GN=murG PE=3 SV=1
B7GGI2 7.23e-86 1 351 1 355
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Anoxybacillus flavithermus (strain DSM 21510 / WK1) OX=491915 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000045 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001430_00397.